{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:08:26Z","timestamp":1792022906631,"version":"4.4.0"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"49","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,12,6]]},"abstract":"<jats:p>\n            Vector mosquito control is an integral part of malaria control. The global emergence of insecticide resistance in malaria-transmitting\n            <jats:italic>Anophelines<\/jats:italic>\n            has become an impediment and has created an urgent need for novel mosquito control approaches. Here, we show that a biopesticide derived from the soil-dwelling bacterium\n            <jats:italic>Chromobacterium<\/jats:italic>\n            sp. Panama (\n            <jats:italic>Csp_P<\/jats:italic>\n            ) kills insecticide-resistant\n            <jats:italic>Anopheles<\/jats:italic>\n            mosquitoes, regardless of their resistance mechanisms. In addition, sublethal dose of\n            <jats:italic>Csp_P<\/jats:italic>\n            acts as a synergist to now used chemical insecticides across multiple classes. Moreover,\n            <jats:italic>Csp_P<\/jats:italic>\n            reduces host-seeking behavior and malaria parasite infection in vector mosquitoes in ways that further decrease transmission. Mosquito glutathione\n            <jats:italic>S<\/jats:italic>\n            -transferases are essential for\n            <jats:italic>Csp_P<\/jats:italic>\n            \u2019s mosquito-killing mechanism. Enclosed field trials in Burkina Faso, conducted in diverse ecological settings and supported by a mathematical model, have now demonstrated its potential for malaria control in settings with widespread insecticide resistance.\n          <\/jats:p>","DOI":"10.1126\/sciadv.ads3658","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T18:59:12Z","timestamp":1733338752000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":13,"title":["<i>Chromobacterium<\/i>\n            biopesticide overcomes insecticide resistance in malaria vector mosquitoes"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5977-6776","authenticated-orcid":true,"given":"Chinmay V.","family":"Tikhe","sequence":"first","affiliation":[{"name":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA."},{"name":"Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4216-134X","authenticated-orcid":true,"given":"Sare","family":"Issiaka","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Sciences de la Sant\u00e9 (IRSS) Direction R\u00e9gionale de l\u2019Ouest, Bobo-Dioulasso, BP 545, Burkina Faso."},{"name":"Universit\u00e9 Joseph Ki-Zerbo, Ouagadougou, 03 BP 7021, Burkina Faso."},{"name":"Institut National de Sant\u00e9 Publique (INSP)\/Centre Muraz, Bobo Dioulasso, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7902-2899","authenticated-orcid":true,"given":"Yuemei","family":"Dong","sequence":"additional","affiliation":[{"name":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA."},{"name":"Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5205-7449","authenticated-orcid":true,"given":"Mary","family":"Kefi","sequence":"additional","affiliation":[{"name":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA."},{"name":"Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5335-9581","authenticated-orcid":true,"given":"Mihra","family":"Tavadia","sequence":"additional","affiliation":[{"name":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA."},{"name":"Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2350-9339","authenticated-orcid":true,"given":"Etienne","family":"Bilgo","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Sciences de la Sant\u00e9 (IRSS) Direction R\u00e9gionale de l\u2019Ouest, Bobo-Dioulasso, BP 545, Burkina Faso."},{"name":"Institut National de Sant\u00e9 Publique (INSP)\/Centre Muraz, Bobo Dioulasso, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8929-2200","authenticated-orcid":true,"given":"Rodrigo M.","family":"Corder","sequence":"additional","affiliation":[{"name":"School of Public Health, University of California Berkley, 2121 Berkeley Way #5328, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0603-7341","authenticated-orcid":true,"given":"John","family":"Marshall","sequence":"additional","affiliation":[{"name":"School of Public Health, University of California Berkley, 2121 Berkeley Way #5328, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9666-9395","authenticated-orcid":true,"given":"Abdoulaye","family":"Diabate","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Sciences de la Sant\u00e9 (IRSS) Direction R\u00e9gionale de l\u2019Ouest, Bobo-Dioulasso, BP 545, Burkina Faso."},{"name":"Institut National de Sant\u00e9 Publique (INSP)\/Centre Muraz, Bobo Dioulasso, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6755-8111","authenticated-orcid":true,"given":"George","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA."},{"name":"Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"World malaria report 2023; https:\/\/who.int\/publications\/i\/item\/9789240086173."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15535"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2015.11.010"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-ento-010814-020828"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1864-1"},{"key":"e_1_3_2_7_2","first-page":"CD012776","article-title":"Piperonyl butoxide (PBO) combined with pyrethroids in insecticide-treated nets to prevent malaria in Africa","volume":"5","author":"Gleave K.","year":"2021","unstructured":"K. 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