{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:06:25Z","timestamp":1792019185625,"version":"4.4.0"},"reference-count":86,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"21","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,5,23]]},"abstract":"<jats:p>Current evidence suggests that the hippocampus is essential for exploiting predictive relationships during perception. However, it remains unclear whether the hippocampus drives the communication of predictions to sensory cortex or receives prediction signals from elsewhere. We collected 7-tesla fMRI data in the medial temporal lobe (MTL) while auditory cues predicted abstract shapes. Strikingly, neural patterns evoked by predicted shapes in CA2\/3, pre\/parasubiculum, and the parahippocampal cortex (PHC) were negatively correlated to patterns evoked by the same shapes when actually presented. Using layer-specific analyses, we ask: In which direction are predictions communicated between the hippocampus and neocortex? Superficial layers of the MTL cortex project to the hippocampus, while the deep layers receive feedback projections. Informational connectivity analyses revealed that communication between CA2\/3 and PHC was specific to the deep layers of PHC. These findings suggest that the hippocampus generates predictions through pattern completion in CA2\/3 and feeds these predictions back to the neocortex.<\/jats:p>","DOI":"10.1126\/sciadv.ads4970","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T13:58:43Z","timestamp":1747835923000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":13,"title":["Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3592-7071","authenticated-orcid":true,"given":"Oliver","family":"Warrington","sequence":"first","affiliation":[{"name":"Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK."},{"name":"Department of Brain Sciences, Imperial College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7473-4363","authenticated-orcid":true,"given":"Nadine N.","family":"Graedel","sequence":"additional","affiliation":[{"name":"Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0374-1659","authenticated-orcid":true,"given":"Martina F.","family":"Callaghan","sequence":"additional","affiliation":[{"name":"Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5153-4959","authenticated-orcid":true,"given":"Peter","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2018.06.002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2020.101821"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0033690"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.06.056"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4284"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0163-18.2018"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31040-w"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2045-21.2022"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.450040319"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.102.3.419"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2013.00074"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1199967"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0805-14.2014"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08080-2"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2019.09.011"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2114171118"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.78677"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53588"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1063(2000)10:4<420::AID-HIPO8>3.0.CO;2-5"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab113"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","unstructured":"J. P. Aggleton K. Christiansen \u201cThe subiculum \u201d in Progress in Brain Research (Elsevier 2015) vol. 219 pp. 65\u201382; https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0079612315000370.","DOI":"10.1016\/bs.pbr.2015.03.003"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6547"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.08.009"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1488-22.2023"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2850"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0049"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4138"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.03.005"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2017.07.016"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/texcom\/tgab045"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063736"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/4580"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.10.003"},{"key":"e_1_3_2_35_2","first-page":"783","article-title":"Attention stabilizes representations in the human hippocampus","volume":"26","author":"Aly M.","year":"2016","unstructured":"M. Aly, N. B. Turk-Browne, Attention stabilizes representations in the human hippocampus. Cereb. Cortex 26, 783\u2013796 (2016).","journal-title":"Cereb. Cortex"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1518931113"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/1.1.1"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001023"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.073"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00015"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1162\/netn_a_00062"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061133"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1850-16.2016"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20933"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2013.03.019"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_01509"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00198477"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1622"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0722-19.2019"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0518-16.2016"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-023-00710-z"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0998-23.2023"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05888-8"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.76143"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.013"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23416"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3008"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2015.24"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2017.06.001"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24297"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2022.863478"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0028681"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.04.030"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3021-18.2019"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.120194"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.70071"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cognition.2024.105961"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf4740"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1163\/156856897X00357"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03202828"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.120294"},{"key":"e_1_3_2_72_2","doi-asserted-by":"crossref","unstructured":"C. Gaser R. Dahnke P. M. Thompson F. Kurth E. Luders Alzheimer\u2019s disease neuroimaging initiative CAT\u2014A computational anatomy toolbox for the analysis of structural MRI data. bioRxiv 495736 [Preprint] (2022); https:\/\/doi.org\/10.1101\/2022.06.11.495736.","DOI":"10.1101\/2022.06.11.495736"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(01)00036-6"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212493"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.12.038"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02864437"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brain.2022.100057"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.03.078"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22627"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23606"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2019.04.001"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117539"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25431-8"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0746"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_3_2_87_2","unstructured":"N. N. Graedel O. Warrington B. Dymerska V. Malekian O. Josephs P. Kok M. F. Callaghan \u201cWhy is 7T fMRI in the ERC so difficult and what can we do about it?\u201d Proceedings of the 31st Annual Meeting of the ISMRM. London UK. (2022)."}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.ads4970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T14:00:19Z","timestamp":1747836019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.ads4970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":86,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025,5,23]]}},"alternative-id":["10.1126\/sciadv.ads4970"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.ads4970","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.03.28.587186","asserted-by":"object"}]},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,23]]},"assertion":[{"value":"2024-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eads4970"}}