{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:43:43Z","timestamp":1785422623925,"version":"3.56.0"},"reference-count":58,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"38","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,9,19]]},"abstract":"<jats:p>\n            The heart functions in two parallel but asymmetric circulations, driven by the right and left ventricles. In the heterotaxy syndrome, abnormal left-right patterning leads to a spectrum of severe congenital heart defects, including ventricle malposition. A postulate anchored in the clinical nomenclature assumes that the looping direction of the embryonic heart tube determines ventricle position at birth. However, this has not been demonstrated experimentally. Here, we performed a unique longitudinal analysis of heterotaxy with right isomerism, using multimodality imaging of\n            <jats:italic toggle=\"yes\">Nodal<\/jats:italic>\n            mouse mutants. Using direct correlations and advanced statistics, we dissected the contribution of heart looping variations to specific structural heart malformations, and uncovered unexpected plasticity of ventricle position after looping in 30% of revertant samples. Genetic tracing and topological associations show that plasticity involves a further step of heart remodeling at E13.5, rather than molecular reprogramming. Human patient scans are consistent with ventricle plasticity and suggest association with poorer prognosis. Our work reveals distinct asymmetric events shaping organs.\n          <\/jats:p>","DOI":"10.1126\/sciadv.ads8192","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:58:44Z","timestamp":1758304724000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Plasticity of ventricle position after heart looping in heterotaxy with right isomerism"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9716-755X","authenticated-orcid":true,"given":"Audrey","family":"Desgrange","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Paris 75006, France."},{"name":"Imagine \u2013 Institut Pasteur, Unit of Heart Morphogenesis, INSERM UMR1163, Paris 75015, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8266-5908","authenticated-orcid":true,"given":"Emeline","family":"Perthame","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Paris 75006, France."},{"name":"Imagine \u2013 Institut Pasteur, Unit of Heart Morphogenesis, INSERM UMR1163, Paris 75015, France."},{"name":"Institut Pasteur, Bioinformatics and Biostatistics Hub, Paris 75015, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Marchiol","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Paris 75006, France."},{"name":"INSERM U1016 and CNRS UMR8104, Institut Cochin, Paris 75014, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2760-3813","authenticated-orcid":true,"given":"Daphn\u00e9","family":"Madec","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Paris 75006, France."},{"name":"Imagine \u2013 Institut Pasteur, Unit of Heart Morphogenesis, INSERM UMR1163, Paris 75015, France."},{"name":"Unit\u00e9 M\u00e9dico-Chirurgicale de Cardiologie Cong\u00e9nitale et P\u00e9diatrique, M3C-Necker, H\u00f4pital Universitaire Necker-Enfant-Malades, APHP, Paris 75015, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5979-5501","authenticated-orcid":true,"given":"Laurent","family":"Guillemot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Paris 75006, France."},{"name":"Imagine \u2013 Institut Pasteur, Unit of Heart Morphogenesis, INSERM UMR1163, Paris 75015, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Amandine","family":"Chabry","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Paris 75006, France."},{"name":"Imagine \u2013 Institut Pasteur, Unit of Heart Morphogenesis, INSERM UMR1163, Paris 75015, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-6619","authenticated-orcid":true,"given":"Mohamed","family":"El Beheiry","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut Curie, PSL Research University, CNRS UMR 168 Physico-Chimie Curie, Paris 75005, France."},{"name":"Institut Pasteur, CNRS UMR 3571, Decision and Bayesian Computation, Paris 75015, France."},{"name":"Epim\u00e9th\u00e9e, INRIA, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-9056","authenticated-orcid":true,"given":"Jean-Baptiste","family":"Masson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Paris 75006, France."},{"name":"Institut Pasteur, CNRS UMR 3571, Decision and Bayesian Computation, Paris 75015, France."},{"name":"Epim\u00e9th\u00e9e, INRIA, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Raisky","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Paris 75006, France."},{"name":"Unit\u00e9 M\u00e9dico-Chirurgicale de Cardiologie Cong\u00e9nitale et P\u00e9diatrique, M3C-Necker, H\u00f4pital Universitaire Necker-Enfant-Malades, APHP, Paris 75015, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3506-6184","authenticated-orcid":true,"given":"S\u00e9gol\u00e8ne","family":"Bernheim","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Paris 75006, France."},{"name":"Imagine \u2013 Institut Pasteur, Unit of Heart Morphogenesis, INSERM UMR1163, Paris 75015, France."},{"name":"Unit\u00e9 M\u00e9dico-Chirurgicale de Cardiologie Cong\u00e9nitale et P\u00e9diatrique, M3C-Necker, H\u00f4pital Universitaire Necker-Enfant-Malades, APHP, Paris 75015, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4024-8599","authenticated-orcid":true,"given":"Lucile","family":"Houyel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Paris 75006, France."},{"name":"Imagine \u2013 Institut Pasteur, Unit of Heart Morphogenesis, INSERM UMR1163, Paris 75015, France."},{"name":"Unit\u00e9 M\u00e9dico-Chirurgicale de Cardiologie Cong\u00e9nitale et P\u00e9diatrique, M3C-Necker, H\u00f4pital Universitaire Necker-Enfant-Malades, APHP, Paris 75015, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4080-2617","authenticated-orcid":true,"given":"Sigol\u00e8ne M.","family":"Meilhac","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Paris 75006, France."},{"name":"Imagine \u2013 Institut Pasteur, Unit of Heart Morphogenesis, INSERM UMR1163, Paris 75015, 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