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Here, we mapped eosinophils across evolutional hepatic granulomas in a mouse model and in a primary wild reservoir for human schistosomiasis in Brazil (water rat\n            <jats:italic toggle=\"yes\">Nectomys squamipes<\/jats:italic>\n            ). With in-depth quantitative image analysis and three-dimensional histological reconstructions of entire granulomas, we find that eosinophils are spatially organized and occupy a major, peripheral niche conserved across space and time in all granuloma stages and both experimental and natural infections. Within this niche, immature and mature eosinophils coinhabit, compartmentalize their major basic protein-1 content, robustly interact with other immune cells, and secrete through piecemeal degranulation. This unveiled niche, unrelated to parasite eggs, challenges the concept of eosinophil as a \u201chelminth killer\u201d cell and invigorates its view as an immunoregulatory cell of the tissue microenvironment in\n            <jats:italic toggle=\"yes\">Schistosoma<\/jats:italic>\n            granulomas.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adt2779","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T17:59:04Z","timestamp":1749664744000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":2,"title":["A major ecological niche of eosinophils in evolving\n            <i>Schistosoma<\/i>\n            granulomas challenges the eosinophil view as \u201chelminth killer\u201d cells"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2553-0935","authenticated-orcid":true,"given":"Luccas M.","family":"Barata","sequence":"first","affiliation":[{"name":"Laboratory of Cellular Biology, Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora (UFJF), Rua Jos\u00e9 Louren\u00e7o Kelmer, Juiz de Fora, MG 36036-900, Brazil."},{"name":"Cell Biology Graduate Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-2719","authenticated-orcid":true,"given":"K\u00e1ssia K.","family":"Malta","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology, Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora (UFJF), Rua Jos\u00e9 Louren\u00e7o Kelmer, Juiz de Fora, MG 36036-900, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5163-5714","authenticated-orcid":true,"given":"Vitor H.","family":"Neves","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology, Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora (UFJF), Rua Jos\u00e9 Louren\u00e7o Kelmer, Juiz de Fora, MG 36036-900, Brazil."},{"name":"Cell Biology Graduate Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0983-0572","authenticated-orcid":true,"given":"Cinthia","family":"Palazzi","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology, Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora (UFJF), Rua Jos\u00e9 Louren\u00e7o Kelmer, Juiz de Fora, MG 36036-900, Brazil."},{"name":"Cell Biology Graduate Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0020-6653","authenticated-orcid":true,"given":"Eliane G.","family":"Oliveira-Barros","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology, Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora (UFJF), Rua Jos\u00e9 Louren\u00e7o Kelmer, Juiz de Fora, MG 36036-900, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3873-9911","authenticated-orcid":true,"given":"Yasmin","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology, Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora (UFJF), Rua Jos\u00e9 Louren\u00e7o Kelmer, Juiz de Fora, MG 36036-900, Brazil."},{"name":"Cell Biology Graduate Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2628-3224","authenticated-orcid":true,"given":"Felipe","family":"Kneip","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology, Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora (UFJF), Rua Jos\u00e9 Louren\u00e7o Kelmer, Juiz de Fora, MG 36036-900, Brazil."},{"name":"Cell Biology Graduate Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5971-8680","authenticated-orcid":true,"given":"Bruno A.","family":"Marcelino","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology, Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora (UFJF), Rua Jos\u00e9 Louren\u00e7o Kelmer, Juiz de Fora, MG 36036-900, Brazil."},{"name":"Biodiversity and Nature Conservation Graduate Program, UFJF, Juiz de Fora, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-3107","authenticated-orcid":true,"given":"L\u00edvia A. 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