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We show that cis interactions between PD-L1 and CD80 are critical for promoting migration and define specific regions within these proteins necessary for migration. Furthermore, we demonstrate that \u03b1PD-L1 significantly impedes DC migration in a B16 melanoma tumor model. Last, we outline how blocking cis PD-L1:CD80 interactions or mutation of the intracellular domain of PD-L1, in an imiquimod-induced murine model of psoriasis, limits DC migration to the lymph node, decreases interleukin-17 production by CD4\n            <jats:sup>+<\/jats:sup>\n            T cells in the lymph node, and reduces epidermal thickening. Therefore, PD-L1 and CD80 interactions are important regulators of DC migration to the draining lymph node.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adt3044","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T19:00:04Z","timestamp":1738177204000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":18,"title":["PD-L1-CD80 interactions are required for intracellular signaling necessary for dendritic cell migration"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5507-8727","authenticated-orcid":true,"given":"Uma","family":"Kantheti","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Aurora, CO, USA."},{"name":"Immunology Graduate Program, University of Colorado School of Medicine, Aurora, CO, USA."},{"name":"Medical Scientist Training Program, University 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