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Here, we present a scalable nanofabrication technique that combines bottom-up and top-down approaches for selective growth of 3D DNA superlattices on gold microarrays. This approach allows for the fabrication of self-assembled 3D-nanostructured electronic devices. DNA strands are bound onto the gold arrays, which anchor DNA origami frames and promote ordered framework growth on the specific areas of the surface, enabling control of the lateral placement and orientation of superlattices. DNA frameworks selectively grown on the pads are subsequently templated to nanoscale silica and tin oxide (SnO\n            <jats:sub>x<\/jats:sub>\n            ) that follow the architecture, as confirmed by structural and chemical characterizations. The fabricated SnO\n            <jats:sub>x<\/jats:sub>\n            superlattices are integrated into devices that demonstrate photocurrent response.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adt5620","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T18:05:49Z","timestamp":1743185149000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":22,"title":["Scalable fabrication of Chip-integrated 3D-nanostructured electronic devices via DNA-programmable assembly"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3060-3788","authenticated-orcid":true,"given":"Aaron","family":"Michelson","sequence":"first","affiliation":[{"name":"Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY 11973, 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USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8229-7108","authenticated-orcid":true,"given":"Nikhil","family":"Tiwale","sequence":"additional","affiliation":[{"name":"Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY 11973, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6824-0367","authenticated-orcid":true,"given":"Hanfei","family":"Yan","sequence":"additional","affiliation":[{"name":"National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY 11973, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5956-7808","authenticated-orcid":true,"given":"Ajith","family":"Pattammattel","sequence":"additional","affiliation":[{"name":"National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY 11973, 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