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Immunofluorescence imaging revealed that FRCs promote CD8\n            <jats:sup>+<\/jats:sup>\n            T cell clustering with type 1 conventional dendritic cells (cDC1) in the T cell zone before migration to the infected marginal zone. Without FRCs, T cells instead clustered with cDC1 and virus-infected cells in the marginal zone, leading to suboptimal priming. Mechanistically, FRCs coordinated early viral replication and the inflammatory milieu for optimal DC activation, and an intact FRC network was crucial for generating effector T cells and maintaining protective memory T cells. Thus, splenic FRCs provide essential lymphoid niches for antiviral T cell responses.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adt5939","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T15:24:10Z","timestamp":1749655450000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":8,"title":["Splenic fibroblastic reticular cells orchestrate dendritic cell maturation and facilitate CD8\n            <sup>+<\/sup>\n            T cell priming and protective memory"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-4098","authenticated-orcid":true,"given":"Yannick O.","family":"Alexandre","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, 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