{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:15:48Z","timestamp":1790266548275,"version":"4.1.0"},"reference-count":42,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"21","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,5,23]]},"abstract":"<jats:p>\n            Dynamic actin cytoskeleton reorganization enables plant developmental processes requiring polarized transport such as root hair and leaf trichome formation. The SCAR\/WAVE complex plays a crucial role in regulating these dynamics through ARP2\/3-mediated actin branching.\n            <jats:italic toggle=\"yes\">SCAR\/WAVE<\/jats:italic>\n            genes occur as small families across a wide range of plant species, but whether and how they fulfill different functions remains unclear. We use a systematic chimera approach to define the differential functionality of two closely related\n            <jats:italic toggle=\"yes\">Medicago truncatula<\/jats:italic>\n            SCAR proteins in plant development. We show that SCAR\/WAVE contribution to\n            <jats:italic toggle=\"yes\">M. truncatula<\/jats:italic>\n            root hair or\n            <jats:italic toggle=\"yes\">Arabidopsis thaliana<\/jats:italic>\n            trichome formation is dependent on two central intrinsically disordered regions (IDRs). Differential functionalities of\n            <jats:italic toggle=\"yes\">M. truncatula<\/jats:italic>\n            SCAR proteins were furthermore associated with the presence\/absence of a 42\u2013amino acid sequence within the IDR that affected protein stability. Through uncovering a molecular basis for functional differences, we advance our understanding of plant SCAR\/WAVE complexes.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adt6107","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T17:58:43Z","timestamp":1747850323000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":4,"title":["Functional divergence of plant SCAR\/WAVE proteins is determined by intrinsically disordered regions"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1498-3880","authenticated-orcid":true,"given":"Sabine","family":"Brumm","sequence":"first","affiliation":[{"name":"Sainsbury Laboratory (SLCU), University of Cambridge, 47 Bateman Street, Cambridge CB2 1LR, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0179-8491","authenticated-orcid":true,"given":"Aleksandr","family":"Gavrin","sequence":"additional","affiliation":[{"name":"Sainsbury Laboratory (SLCU), University of Cambridge, 47 Bateman Street, Cambridge CB2 1LR, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6353-4820","authenticated-orcid":true,"given":"Matthew","family":"Macleod","sequence":"additional","affiliation":[{"name":"Sainsbury Laboratory (SLCU), University of Cambridge, 47 Bateman Street, Cambridge CB2 1LR, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5516-1918","authenticated-orcid":true,"given":"Guillaume","family":"Chesneau","sequence":"additional","affiliation":[{"name":"Sainsbury Laboratory (SLCU), University of Cambridge, 47 Bateman Street, Cambridge CB2 1LR, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7283-4061","authenticated-orcid":true,"given":"Annika","family":"Usl\u00e4nder","sequence":"additional","affiliation":[{"name":"Sainsbury Laboratory (SLCU), University of Cambridge, 47 Bateman Street, Cambridge CB2 1LR, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7836-5881","authenticated-orcid":true,"given":"Sebastian","family":"Schornack","sequence":"additional","affiliation":[{"name":"Sainsbury Laboratory (SLCU), University of Cambridge, 47 Bateman Street, Cambridge CB2 1LR, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2023.102370"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2023.102365"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/pce.14450"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202307066"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6181"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20286-x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.011676"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2004.02065.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.103.028563"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.105.033266"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2013.00166"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.104.027987"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02792"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02280"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-06-10-0144"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.104.053173"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.107.055350"},{"key":"e_1_3_2_19_2","first-page":"925","article-title":"A role for ABIL3 in plant cell morphogenesis","volume":"62","author":"J\u00f6rgens C. 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