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We present Spatial transcriptOmics Analysis Resource (SOAR), a comprehensive spatial transcriptomics platform with 3461 uniformly processed samples across 13 species, 42 tissue types, and 19 different spatial transcriptomics technologies. Using SOAR, we found that\n                    <jats:italic toggle=\"yes\">CXCL16<\/jats:italic>\n                    \/\n                    <jats:italic toggle=\"yes\">SPP1<\/jats:italic>\n                    macrophage polarity characterizes the coordination of immune cell polarity in the tumor microenvironment. SOAR\u2019s integrative approach toward drug discovery revealed sirolimus and trichostatin A as potential anticancer agents targeting the phosphatidylinositol 3-kinase\/Akt\/mammalian target of rapamycin growth and proliferation pathway and identified Janus kinase\/signal transducers and activators of transcription inhibitors for ulcerative colitis treatment. SOAR\u2019s results demonstrate its broad application to data generated from diverse spatial technologies and pathological conditions. SOAR will support future benchmarking studies and method development, facilitating discoveries in molecular functions, disease mechanisms, and potential therapeutic targets.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adt7450","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T13:59:04Z","timestamp":1749650344000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":10,"title":["SOAR elucidates biological insights and empowers drug discovery through spatial transcriptomics"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2111-3939","authenticated-orcid":true,"given":"Yiming","family":"Li","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University, Chicago, IL 60611, 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