{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:01:22Z","timestamp":1792414882950,"version":"4.4.0"},"reference-count":53,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"18","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,5,2]]},"abstract":"<jats:p>\n                    Clonal hematopoiesis (CH) becomes more prevalent with aging and may influence inflammatory diseases by altering immune function. While CH of indeterminate potential (CHIP) promotes inflammation in nonmalignant conditions, its relationship with rheumatoid arthritis (RA) remains unknown. We analyzed CHIP mutations in RA using two population-level cohorts and patients with newly diagnosed RA. CHIP was associated with prevalent RA in 10,089 FINRISK study participants with whole-exome sequencing (OR,\u00a02.06;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0=\u00a00.029) and in the FinnGen cohort (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u00a0=\u00a0520,210; OR,\u00a01.49;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) using single-nucleotide polymorphism array\u2013based CHIP annotation. In FinnGen, CHIP was also associated with inferior overall survival in participants with RA (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0=\u00a00.013). In newly diagnosed RA (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u00a0=\u00a0573),\n                    <jats:italic toggle=\"yes\">DNMT3A<\/jats:italic>\n                    -mutated seropositive patients had increased inflammatory markers and disease activity compared with patients without CHIP. In contrast,\n                    <jats:italic toggle=\"yes\">TET2<\/jats:italic>\n                    mutations were enriched in seronegative RA (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0=\u00a00.009). Our findings provide further evidence for the context-dependent association between CHIP and inflammation, with potential therapeutic implications.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adt9846","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T22:03:58Z","timestamp":1746050638000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":17,"title":["Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1742-5762","authenticated-orcid":true,"given":"Emil","family":"Hiitola","sequence":"first","affiliation":[{"name":"Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland."},{"name":"Translational Immunology Research program, University of Helsinki, Helsinki, Finland."},{"name":"iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1668-2878","authenticated-orcid":true,"given":"Juuso","family":"Korhonen","sequence":"additional","affiliation":[{"name":"Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland."},{"name":"Translational Immunology Research program, University of Helsinki, Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-5364","authenticated-orcid":true,"given":"Heidi","family":"Kokkonen","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine\/Rheumatology, Ume\u00e5 University, Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0154-7222","authenticated-orcid":true,"given":"Jukka","family":"Koskela","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4714-9481","authenticated-orcid":true,"given":"Matti","family":"Kankainen","sequence":"additional","affiliation":[{"name":"Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland."},{"name":"Translational Immunology Research program, University of Helsinki, Helsinki, Finland."},{"name":"iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8158-7032","authenticated-orcid":true,"given":"Milla","family":"Alakuijala","sequence":"additional","affiliation":[{"name":"Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland."},{"name":"Translational Immunology Research program, University of Helsinki, Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9155-1494","authenticated-orcid":true,"given":"Aoxing","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland."},{"name":"Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA."},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA."},{"name":"Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA."},{"name":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3146-9816","authenticated-orcid":true,"given":"Sofie","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland."},{"name":"Translational Immunology Research program, University of Helsinki, Helsinki, Finland."},{"name":"iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8502-0582","authenticated-orcid":true,"given":"Paavo","family":"H\u00e4pp\u00f6l\u00e4","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Finland, University of 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of Helsinki, Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riitta","family":"Lahesmaa","sequence":"additional","affiliation":[{"name":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, Turku, Finland."},{"name":"InFLAMES Research Flagship Center, University of Turku, Turku, Finland."},{"name":"Institute of Biomedicine, University of Turku, Turku, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0747-9512","authenticated-orcid":true,"given":"Olli","family":"Silvennoinen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland."},{"name":"Institute of Biotechnology, HiLIFE Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland."},{"name":"FIMLAB Laboratories, Tampere, 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