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The MEF group had worse prognosis, higher fungal diversity, down-regulated lipid catabolism, and exhausted CD8\n            <jats:sup>+<\/jats:sup>\n            T cells. We developed the intratumoral mycobiota signature and intratumoral mycobiota-related genes expression signature, which robustly predicted prognosis and immunotherapy outcomes in RCC and other cancers.\n            <jats:italic>Aspergillus tanneri<\/jats:italic>\n            was identified as a potential key fungal species influencing RCC prognosis. Our findings suggest that the intratumoral mycobiome suppresses lipid catabolism and induces T cell exhaustion in RCC.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adu1727","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T17:58:41Z","timestamp":1744221521000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":36,"title":["Intratumoral mycobiome heterogeneity influences the tumor microenvironment and immunotherapy outcomes in renal cell carcinoma"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1089-6516","authenticated-orcid":true,"given":"Weiming","family":"Mou","sequence":"first","affiliation":[{"name":"Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China."},{"name":"Donghai County People\u2019s Hospital\u2013Jiangnan University Smart Healthcare Joint Laboratory, Lianyungang 222000, China."},{"name":"Department 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