{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T23:40:46Z","timestamp":1773186046820,"version":"3.50.1"},"reference-count":35,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"16","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,4,18]]},"abstract":"<jats:p>Sex differences in the pathogenesis of a variety of diseases have drawn increasing attention. However, it remains unclear whether such differences exist in chemotherapy-induced neuropathic pain. Here, we conducted a retrospective analysis of clinical case data and found that peripheral sensory disorders occurred earlier in females than in males following bortezomib (BTZ) treatment in patients with multiple myeloma. BTZ treatment led to an early elevation of intercellular adhesion molecule\u20131, which triggered the infiltration of peripheral monocytes into the perivascular region of the spinal cord in female mice. The CC-chemokine ligand 1 released by infiltrating macrophages directly activated neurons or indirectly activated neurons by enhancing the astrocyte activity, ultimately leading to the earlier onset of BTZ-induced neuropathic pain in females. Together, clarifying the mechanism underlying the earlier onset of BTZ-induced neuropathic pain will contribute to the precise treatment of multiple myeloma in females.<\/jats:p>","DOI":"10.1126\/sciadv.adu2159","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T17:58:56Z","timestamp":1744826336000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Earlier onset of chemotherapy-induced neuropathic pain in females by ICAM-1\u2013mediated accumulation of perivascular macrophages"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4752-4314","authenticated-orcid":true,"given":"Li","family":"Chen","sequence":"first","affiliation":[{"name":"Guangdong Province Key Laboratory of Brain Function and Disease, Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou 510080, 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