{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:10:58Z","timestamp":1790647858313,"version":"4.1.0"},"reference-count":49,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"23","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,6,6]]},"abstract":"<jats:p>\n            Chimeric antigen receptor (CAR) T cells have limited efficacy against solid tumors including neuroblastoma. Here, we evaluated whether low-dose radiation delivered by radiopharmaceutical therapy (RPT), known to potentiate immune checkpoint inhibitors, can synergize with CRISPR-edited GD2\n            <jats:italic toggle=\"yes\">TRAC-<\/jats:italic>\n            CAR T cells to improve outcomes in neuroblastoma. We found that in the localized model of neuroblastoma, low-dose radiation delivered by\n            <jats:sup>177<\/jats:sup>\n            Lu-NM600, an alkylphosphocholine mimetic RPT agent, followed 9 days later by GD2\n            <jats:italic toggle=\"yes\">TRAC-<\/jats:italic>\n            CAR T cells led to complete tumor regression. Irradiation of neuroblastoma before GD2\n            <jats:italic toggle=\"yes\">TRAC-<\/jats:italic>\n            CAR T cells enhanced the release by CAR T cells of perforin, granzyme B, tumor necrosis factor\u2013\u03b1, and interleukin-7 while abrogating transforming growth factor\u2013\u03b21. Low-dose RPT up-regulated the death receptor Fas on neuroblastoma, potentially enabling CAR-independent killing. This suggests that low-dose RPT can enhance suboptimal CAR T cell efficacy against solid tumors. However, optimization of radiation dose and timing may be needed for each patient and RPT agent to account for varied tumor radiosensitivity and dosimetry.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adu4417","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T15:23:43Z","timestamp":1749655423000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":13,"title":["Low-dose radiation by radiopharmaceutical therapy enhances GD2\n            <i>TRAC<\/i>\n            -CAR T cell efficacy in localized neuroblastoma"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-1388","authenticated-orcid":true,"given":"Quaovi H.","family":"Sodji","sequence":"first","affiliation":[{"name":"Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA."},{"name":"Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, 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