{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:46:47Z","timestamp":1791582407311,"version":"4.3.4"},"reference-count":91,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"19","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,5,9]]},"abstract":"<jats:p>\n                    According to the plant vigor hypothesis, younger, more vigorous plants tend to be more susceptible to herbivores compared to older, mature plants, yet the molecular mechanisms underlying this dynamic remain elusive. Here, we uncover a hormonal cross-talk framework that orchestrates the age-related balance between plant growth and herbivore defense. We demonstrate that the accumulation of salicylic acid (SA), synthesized by\n                    <jats:italic toggle=\"yes\">Nicotiana benthamiana<\/jats:italic>\n                    phenylalanine ammonia-lyase 6 (NbPAL6), dictates insect resistance in adult plants.\n                    <jats:italic toggle=\"yes\">NbPAL6<\/jats:italic>\n                    expression is driven by the key transcription factor, NbMYB42, which is regulated by two interacting auxin response factors, NbARF18La\/b. In juvenile plants, higher auxin levels activate\n                    <jats:italic toggle=\"yes\">Nb<\/jats:italic>\n                    miR160c, a microRNA that simultaneously silences\n                    <jats:italic toggle=\"yes\">NbARF18La\/b<\/jats:italic>\n                    , subsequently reducing\n                    <jats:italic toggle=\"yes\">NbMYB42<\/jats:italic>\n                    expression, lowering SA accumulation, and thus weakening herbivore defense. Excessive SA in juvenile plants enhances defense but antagonizes auxin signaling, impairing early growth. Our findings suggest a seesaw-like model that balances growth and defense depending on the plant\u2019s developmental stage.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adu5141","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T13:58:21Z","timestamp":1746799101000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":26,"title":["Auxin-salicylic acid seesaw regulates the age-dependent balance between plant growth and herbivore defense"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0219-9507","authenticated-orcid":true,"given":"Wen-Hao","family":"Han","sequence":"first","affiliation":[{"name":"State Key Laboratory of Rice Biology and Breeding, Ministry of Agriculture and Rural Affairs Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4041-8770","authenticated-orcid":true,"given":"Feng-Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rice Biology and Breeding, Ministry of Agriculture and Rural Affairs Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5284-6190","authenticated-orcid":true,"given":"Shun-Xia","family":"Ji","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rice Biology and Breeding, Ministry of Agriculture and Rural Affairs Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Lu","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rice Biology and Breeding, Ministry of Agriculture and Rural Affairs Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rice Biology and Breeding, Ministry of Agriculture and Rural Affairs Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9929-6296","authenticated-orcid":true,"given":"Xiao-Ping","family":"Fan","sequence":"additional","affiliation":[{"name":"LC-Bio Technology Co. 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