{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:33:54Z","timestamp":1790296434407,"version":"4.1.0"},"reference-count":85,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"16","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,4,18]]},"abstract":"<jats:p>\n            Like many organisms, the roundworm\n            <jats:italic>Caenorhabditis elegans<\/jats:italic>\n            incorporates an assessment of environmental quality into its reproductive strategy.\n            <jats:italic>C. elegans<\/jats:italic>\n            hermaphrodites release fertilized eggs into food-rich environments but retain them in the absence of food. Here, we report the discovery of a neural circuit required for the modulation of reproductive behavior by food sensing. A mutation that electrically silences the AVK interneurons uncouples egg laying from detection of environmental food cues. We find that AVK activity inhibits egg laying, and AVKs themselves are inhibited by dopamine released from food-sensing neurons. AVKs express a large number of structurally and functionally diverse neuropeptides. Coordination of food-sensing and reproductive behavior requires a subset of AVK neuropeptides that converge on a small ensemble of premotor neurons that coexpress their cognate receptors. Modulation of\n            <jats:italic>C. elegans<\/jats:italic>\n            reproductive behavior, therefore, requires a cascade of neuromodulatory signals that uses disinhibition and combinatorial neuropeptide signals to activate reproductive behavior when food is sensed.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adu5829","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T17:58:56Z","timestamp":1744826336000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":6,"title":["Food sensing controls\n            <i>C. elegans<\/i>\n            reproductive behavior by neuromodulatory disinhibition"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5110-7436","authenticated-orcid":true,"given":"Yen-Chih","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara E.","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5862-1956","authenticated-orcid":true,"given":"Hassan","family":"Ahamed","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8679-2269","authenticated-orcid":true,"given":"Niels","family":"Ringstad","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068287"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.2007.00030.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1151842"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6805073"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/104.4.619"},{"key":"e_1_3_2_7_2","first-page":"107","article-title":"Facultative vivipary is a life-history trait in Caenorhabditis elegans","volume":"36","author":"Chen J.","year":"2004","unstructured":"J. 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