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This sonoelectric niche induces nucleus pulposus cell (NPC) membrane depolarization, activating calcium voltage-gated channels (Ca\n            <jats:sub>v<\/jats:sub>\n            ) to drive Ca\n            <jats:sup>2+<\/jats:sup>\n            influx. Subsequent calcium- and calmodulin-dependent protein kinase I activation up-regulates cyclin-dependent kinases CDK1\/CDK2, forming a sonoelectricity\u2013ion\u2013kinase axis that stimulates NPC proliferation and anabolism. Concurrently, ultrasound-responsive borate ester bonds in the hydrogel amplify reactive oxygen species scavenging, counteracting oxidative stress\u2013induced NPC ferroptosis. In a goat model of intervertebral disc degeneration, ultrasound-guided hydrogel implantation alleviated degenerative progression by synergistically reactivating cell cycle progression and suppressing oxidative damage. This strategy demonstrates a noninvasive, dual-targeted approach to regulate degenerative microenvironments through spatiotemporal control of sonoelectric and biochemical cues, offering a translatable strategy for tissue regeneration therapies.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adu6860","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T17:58:46Z","timestamp":1754675926000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":10,"title":["A sonoelectric niche for noninvasive intervertebral disc regeneration via targeted cell cycle modulation"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-5245","authenticated-orcid":true,"given":"Xiaoguang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, 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