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Here, we tested this hypothesis in mice modeling the human Ca\n            <jats:sub>V<\/jats:sub>\n            1.3\n            <jats:sup>A749G<\/jats:sup>\n            mutation that causes low-voltage Ca\n            <jats:sup>2+<\/jats:sup>\n            channel activation. We demonstrate activation of Ca\n            <jats:sup>2+<\/jats:sup>\n            influx and glutamate release of IHC AZs at lower voltages, increased spontaneous firing in SGNs, and lower sound threshold of Ca\n            <jats:sub>V<\/jats:sub>\n            1.3\n            <jats:sup>A749G\/A749G<\/jats:sup>\n            mice. Loss of synaptic ribbons in IHCs at ambient sound levels of mouse husbandry indicates that low-voltage Ca\n            <jats:sup>2+<\/jats:sup>\n            channel activation poses a risk for noise-induced synaptic damage. We propose that the heterogeneous voltage dependence of Ca\n            <jats:sub>V<\/jats:sub>\n            1.3 activation among presynaptic IHC AZs contributes to the diversity of firing among the postsynaptic SGNs.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adu7898","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T18:00:58Z","timestamp":1750269658000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":10,"title":["Gating of hair cell Ca\n            <sup>2+<\/sup>\n            channels governs the activity of cochlear neurons"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3999-2427","authenticated-orcid":true,"given":"Nare","family":"Karagulyan","sequence":"first","affiliation":[{"name":"Institute for Auditory Neuroscience and InnerEarLab, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany."},{"name":"Auditory Neuroscience &amp; Synaptic Nanophysiology Group, Max Planck Institute for Multidisciplinary Sciences, G\u00f6ttingen, Germany."},{"name":"G\u00f6ttingen Graduate School for Neurosciences and Molecular Biosciences, University of G\u00f6ttingen, G\u00f6ttingen, Germany."},{"name":"Cluster of Excellence \u201cMultiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells\u201d (MBExC), University of G\u00f6ttingen, G\u00f6ttingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3624-0343","authenticated-orcid":true,"given":"Anupriya","family":"Thirumalai","sequence":"additional","affiliation":[{"name":"Institute for Auditory Neuroscience and InnerEarLab, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany."},{"name":"Auditory Neuroscience &amp; 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