{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:03:46Z","timestamp":1792299826012,"version":"4.4.0"},"reference-count":88,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"48","funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["964529"],"award-info":[{"award-number":["964529"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002957","name":"Dresden University of Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002957","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100015022","name":"Saxon State and University Library Dresden","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015022","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,11,28]]},"abstract":"<jats:p>\n                    Smell loss is a sensory impairment that has major consequences in many areas of daily life and for which current therapies are insufficient. A prosthesis-type technology enabling patients to sample their olfactory environment has not yet been developed. The aim of our study was, therefore, to test whether stimulation of the intranasal trigeminal system by a device combining an artificial nose with an intranasal electrical stimulator will enable patients to detect and discriminate odorant molecules. Four experiments involving normosmic individuals (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u00a0=\u00a013) and patients with olfactory loss (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u00a0=\u00a052) showed that individuals were able to detect their olfactory environment using the device. For discrimination, the results are less clear-cut but show that most patients can distinguish between two external stimuli. Although this substitution approach does not allow patients to smell real odors, it is a genuine first substitution solution that we could imagine offering to patients in the future.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adu7926","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T19:01:51Z","timestamp":1764183711000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":6,"title":["Substitution of human olfaction by the trigeminal system"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6043-4669","authenticated-orcid":true,"given":"Halina B.","family":"Stanley","sequence":"first","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, NEUROPOP, F-69500 Bron, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7361-1385","authenticated-orcid":true,"given":"Cl\u00e9mentine","family":"Lipp","sequence":"additional","affiliation":[{"name":"Microsystems Laboratory, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-7186","authenticated-orcid":true,"given":"Coralie","family":"Mignot","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Carl Gustav Carus Faculty of Medicine, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7650-1731","authenticated-orcid":true,"given":"Susanne","family":"Weise","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Carl Gustav Carus Faculty of Medicine, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3905-5650","authenticated-orcid":true,"given":"Konstantinos","family":"Garefis","sequence":"additional","affiliation":[{"name":"2nd Academic ORL, Head and Neck Surgery Department, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Fieux","sequence":"additional","affiliation":[{"name":"Hospices civils de Lyon, H\u00f4pital Lyon Sud, Service d\u2019ORL, d\u2019otoneurochirurgie et de chirurgie cervico-faciale, F-69310 Pierre B\u00e9nite, France."},{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, F-69003 Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Tsakiropoulou","sequence":"additional","affiliation":[{"name":"2nd Academic ORL, Head and Neck Surgery Department, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotiria","family":"Genetzaki","sequence":"additional","affiliation":[{"name":"2nd Academic ORL, Head and Neck Surgery Department, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Dubreuil","sequence":"additional","affiliation":[{"name":"Aryballe, 7 rue des arts et m\u00e9tiers, 38000 Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-0361","authenticated-orcid":true,"given":"Camille","family":"Ferdenzi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, NEUROPOP, F-69500 Bron, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2101-5474","authenticated-orcid":true,"given":"Marina","family":"Carulli","sequence":"additional","affiliation":[{"name":"Dipartimento di Meccanica, Politecnico di Milano, Via La Masa 1, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5256-181X","authenticated-orcid":true,"given":"Michele","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Dipartimento di Meccanica, Politecnico di Milano, Via La Masa 1, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2714-9043","authenticated-orcid":true,"given":"Marco","family":"Rossoni","sequence":"additional","affiliation":[{"name":"Dipartimento di Meccanica, Politecnico di Milano, Via La Masa 1, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1044-0478","authenticated-orcid":true,"given":"Arnaud","family":"Bertsch","sequence":"additional","affiliation":[{"name":"Microsystems Laboratory, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7710-5930","authenticated-orcid":true,"given":"Juergen","family":"Brugger","sequence":"additional","affiliation":[{"name":"Microsystems Laboratory, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-0183","authenticated-orcid":true,"given":"Thomas","family":"Hummel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Carl Gustav Carus Faculty of Medicine, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iordanis","family":"Konstantinidis","sequence":"additional","affiliation":[{"name":"2nd Academic ORL, Head and Neck Surgery Department, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2991-3036","authenticated-orcid":true,"given":"Moustafa","family":"Bensafi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, NEUROPOP, F-69500 Bron, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjp083"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjt072"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino16.248"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12078-017-9237-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjab028"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodqual.2021.104273"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200404000-00026"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200410000-00017"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin22.483"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjaa041"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-024-00510-1"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27476"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2020.128342"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/299352a0"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2021.130846"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000740"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1049\/iet-nbt.2010.0032"},{"key":"e_1_3_2_19_2","first-page":"460","article-title":"Ueber elektrische geruchsempfindung","volume":"33","author":"Aronsohn E.","year":"1884","unstructured":"E. Aronsohn, Ueber elektrische geruchsempfindung. Arch. F\u00fcr Physiol. 33, 460\u2013465 (1884). [On electrical olfactory perception].","journal-title":"Arch. F\u00fcr Physiol."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22237"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.03.027"},{"key":"e_1_3_2_22_2","first-page":"351","article-title":"Neurophysiopathology of olfaction in man","volume":"54","author":"Uziel A.","year":"1978","unstructured":"A. Uziel, Neurophysiopathology of olfaction in man. Sem. Hopitaux Organe Fonde Par Assoc. Enseign. Med. Hopitaux Paris 54, 351\u2013352 (1978).","journal-title":"Sem. Hopitaux Organe Fonde Par Assoc. Enseign. Med. Hopitaux Paris"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw222"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22133"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2020.107559"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119438"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000529040"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000529563"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-022-01249-8"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.11.017"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1551-6709.2009.01040.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2003.10.013"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh380"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.169612"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2017.11.007"},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","unstructured":"J. Brooks \u00c1. Kristj\u00e1nsson R. Unnthorsson \u201cSensory substitution: Visual information via haptics \u201d in Somatosensory Research Methods N. P. Holmes Ed. (Springer 2023) pp. 287\u2013302https:\/\/doi.org\/10.1007\/978-1-0716-3068-6_14.","DOI":"10.1007\/978-1-0716-3068-6_14"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001273"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1068\/p5631"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1068\/p6952"},{"key":"e_1_3_2_40_2","unstructured":"MetaModal LLC - The vOICe; www.metamodal.com\/."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0286512"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237344"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033136"},{"key":"e_1_3_2_44_2","unstructured":"The vOICe - New Frontiers in Artificial Vision; www.seeingwithsound.com\/."},{"key":"e_1_3_2_45_2","unstructured":"Blind User Preferences for Sensory Substitution Devices (SCHI Lab) (2017); www.youtube.com\/watch?v=ha0aL2VAwCw."},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.2196\/49969"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/22.4.447"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bju064"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2021.3100851"},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","unstructured":"T. Hummel J. Frasnelli \u201cChapter 8 - The intranasal trigeminal system \u201d in Handbook of Clinical Neurology R. L. Doty Ed. (Elsevier 2019) vol. 164 pp. 119\u2013134; www.sciencedirect.com\/science\/article\/pii\/B9780444638557000083.","DOI":"10.1016\/B978-0-444-63855-7.00008-3"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185543"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000224764.61959.e8"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(78)90070-7"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63855-7.00025-3"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-06708-6"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/221963a0"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.3390\/s22051859"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00815"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-55429-3"},{"key":"e_1_3_2_60_2","first-page":"e64266","article-title":"Assessment of audio-tactile sensory substitution training in participants with profound deafness using the event-related potential technique","author":"Ruiz-Stovel V. D.","year":"2022","unstructured":"V. D. Ruiz-Stovel, A. A. Gonz\u00e1lez-Garrido, F. R. G\u00f3mez-Vel\u00e1zquez, G. B. Gallardo-Moreno, E. R. Villuendas-Gonz\u00e1lez, C. A. Soto-Nava, Assessment of audio-tactile sensory substitution training in participants with profound deafness using the event-related potential technique. J. Vis. Exp., e64266 (2022).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-24-10829.2002"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.16420"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006945"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1158-07.2007"},{"key":"e_1_3_2_65_2","unstructured":"M. Bensafi T. Livache C. Herrier C. Ferdenzi R. Dubreuil Proc\u00e9d\u00e9s et syst\u00e8mes de substitution sensorielle de l\u2019odorat chez un sujet (2024); https:\/\/patents.google.com\/patent\/WO2024200803A1\/fr. [Methods and systems for the sensory substitution of smell in a subject]."},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0014345"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.10.034"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53752-2.00003-5"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24390"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104853"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20101"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23801"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1080\/00222895.2014.931273"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjj012"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13490"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211175"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10143"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjm004"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjr001"},{"key":"e_1_3_2_80_2","doi-asserted-by":"crossref","unstructured":"J. Brooks S.-Y. Teng J. Wen R. Nith J. Nishida P. Lopes \u201cStereo-smell via electrical trigeminal stimulation \u201d in Proceedings of the 2021 CHI Conference on Human Factors in Computing Systems (ACM 2021) pp. 1\u201313; https:\/\/dl.acm.org\/doi\/10.1145\/3411764.3445300.","DOI":"10.1145\/3411764.3445300"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26510-5"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23164"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1037\/h0025848"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0173-0"},{"key":"e_1_3_2_85_2","unstructured":"jamovi The jamovi project version 2.3 (2022); www.jamovi.org."},{"key":"e_1_3_2_86_2","unstructured":"R Core Team R: A Language and environment for statistical computing version 4.1 (2021) (R packages retrieved from MRAN snapshot 2022-01-01); https:\/\/cran.r-project.org."},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.70055"},{"key":"e_1_3_2_88_2","doi-asserted-by":"crossref","unstructured":"C. Lipp E. Glushkov H. B. Stanley C. Ferdenzi M. Fieux A. Bertsch J. Brugger M. Bensafi \u201cStimulation of the nasal cavity using flexible PCB electrodes \u201d in Proceedings XXXV EUROSENSORS Conference (MDPI 2024) p. 231https:\/\/doi.org\/10.3390\/proceedings2024097231.","DOI":"10.3390\/proceedings2024097231"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)03336-5"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adu7926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T19:30:20Z","timestamp":1765481420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adu7926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":88,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2025,11,28]]}},"alternative-id":["10.1126\/sciadv.adu7926"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adu7926","relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.1126\/science.aee4566","asserted-by":"subject"}]},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"assertion":[{"value":"2024-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadu7926"}}