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SiglecF\n                    <jats:sup>low<\/jats:sup>\n                    profibrotic airway macrophages were more prevalent in lung tumor-bearing mice than tumor-free mice. This profibrotic subset was reduced in lungs when the cancer model was crossed to\n                    <jats:italic toggle=\"yes\">Tcrd<\/jats:italic>\n                    knockout mice or treated with V\u03b31-depleting antibodies but not in\n                    <jats:italic toggle=\"yes\">TcrgV4\/6<\/jats:italic>\n                    knockout mice. Thus, our findings implicate V\u03b31 \u03b3\u03b4 T cells in driving tumor-associated airway macrophage functional imprinting. Determining the translatability to human health may offer new avenues for refining patient management and immunotherapeutic strategies.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adu8802","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T18:58:52Z","timestamp":1772650732000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["V\u03b31 \u03b3\u03b4 T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8891-4821","authenticated-orcid":true,"given":"Ximena L.","family":"Raffo-Iraolagoitia","sequence":"first","affiliation":[{"name":"Cancer Research UK Scotland Institute, Glasgow, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"McFarlane","sequence":"additional","affiliation":[{"name":"Cancer Research UK Scotland Institute, Glasgow, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3761-5749","authenticated-orcid":true,"given":"Sarah","family":"Laing","sequence":"additional","affiliation":[{"name":"School of Cancer Sciences, University of Glasgow, Glasgow, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6488-0495","authenticated-orcid":true,"given":"Ryan","family":"Corbyn","sequence":"additional","affiliation":[{"name":"Cancer Research UK Scotland Institute, Glasgow, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey W. 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