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Adv."],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:p>\n                    Lateralization is a hallmark of brain organization, yet the structural basis underlying this phenomenon remains a critical, unresolved question in cognitive and systems neuroscience. In this study, we applied multivariate machine learning techniques to investigate variations of global brain asymmetry and their associations with cognitive functions, aging, and aging-related diseases, using large-scale datasets. Our findings revealed substantial and previously unknown structural differences between the hemispheres, and established key associations between structural asymmetries and lateralized functions. At the population level, we identified unique aging trajectories of hemispheric differences and uncovered diagnosis-specific variations in patients with Alzheimer\u2019s and Parkinson\u2019s disease, and in\n                    <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                    \u03b54 carriers at genetic risk. Notably, we identified a \u201cleft hemi-aging\u201d pattern that challenges the conventional \u201cright hemi-aging\u201d model. Together, these results advance our understanding of functional lateralization in the human brain and highlight the potential of global brain asymmetry as a biomarker for brain aging and related diseases.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adu9309","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:59:22Z","timestamp":1782928762000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Variations of global brain asymmetry are associated with aging and related diseases"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2290-9333","authenticated-orcid":true,"given":"Haoyu","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China."},{"name":"The State Key Lab of Brain-Machine Intelligence, Zhejiang University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0785-6817","authenticated-orcid":true,"given":"Duxiao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China."},{"name":"The State Key Lab of Brain-Machine Intelligence, Zhejiang University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8816-6133","authenticated-orcid":true,"given":"Yi","family":"Pu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilamujiang","family":"Abuduaini","sequence":"additional","affiliation":[{"name":"Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China."},{"name":"The State Key Lab of Brain-Machine Intelligence, Zhejiang University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5226-9907","authenticated-orcid":true,"given":"Xichunwang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China."},{"name":"The State Key Lab of Brain-Machine Intelligence, Zhejiang University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9098-890X","authenticated-orcid":true,"given":"Clyde","family":"Francks","sequence":"additional","affiliation":[{"name":"Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands."},{"name":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands."},{"name":"Department of Medical Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4720-8867","authenticated-orcid":true,"given":"Paul M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark &amp; Mary Stevens Neuroimaging &amp; Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0805-1350","authenticated-orcid":true,"given":"Xiang-Zhen","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China."},{"name":"The State Key Lab of Brain-Machine Intelligence, Zhejiang University, Hangzhou, China."},{"name":"Department of Psychiatry of Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China."},{"name":"Zhejiang Key Laboratory of Neurocognitive Development and Mental Health, Zhejiang University, Hangzhou, Zhejiang."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"L. 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