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Adv."],"published-print":{"date-parts":[[2025,12,12]]},"abstract":"<jats:p>\n                    Emerging evidence demonstrates that self-reactive CD8\n                    <jats:sup>+<\/jats:sup>\n                    T resident memory cells (T\n                    <jats:sub>RM<\/jats:sub>\n                    cells) may already populate the never-lesional (NL) skin of patients with chronic inflammatory conditions, including vitiligo. However, their functional activity and regulation remain unknown. By combining cellular and transcriptomic approaches, we show that common CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell clusters with a similar transcriptional profile infiltrate NL and peri-lesional (PL) skin of patients with vitiligo. Pathways related to immune activation were more active in T cells from PL skin, while those related to immune regulation were enriched in NL skin T cells, also evidenced by the stronger infiltration of regulatory T cells and the higher expression of programmed cell death protein 1 (PD-1) by CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in NL skin. Treatment of patients with baricitinib led to an increase in regulatory T cells and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells expressing PD-1 in repigmented skin. These findings suggest that functional T cells populate pigmented skin in vitiligo and highlight the importance of regulatory mechanisms to restrain their activation and prevent depigmentation.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adu9360","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T18:58:43Z","timestamp":1765393123000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Immune control of functional memory CD8 T cells in normal-appearing vitiligo skin"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-1923","authenticated-orcid":true,"given":"Laure","family":"Migayron","sequence":"first","affiliation":[{"name":"CNRS, ImmunoConcEpT, UMR 5164, Univ. 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