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Here, we examine maturation of an MA triple mutant, L20K\/E73K\/A82T, which, despite replicating similarly to wild-type (WT) in some cell lines, exhibits distinct biochemical behaviors that suggest altered MA-MA interactions. Cryo\u2013electron tomography with subtomogram averaging reveals that, although the MA lattice in immature L20K\/E73K\/A82T virions closely resembles that of the WT, mature L20K\/E73K\/A82T virions lack a detectable MA lattice. All-atom molecular dynamics simulations suggest that this absence results from destabilized inter-trimer MA interactions in mature L20K\/E73K\/A82T mutant virions. 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