{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:32:36Z","timestamp":1788449556976,"version":"build-2803163510"},"reference-count":65,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"35","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,8,29]]},"abstract":"<jats:p>Papillary thyroid carcinoma (PTC) generally has a favorable prognosis; however, overtreatment persists because of the lack of reliable noninvasive risk stratification tools. This study developed a radiomics-based approach to enhance the preoperative assessment of PTC. Imaging features from 255 patients were analyzed, and three tumor clusters were identified via unsupervised clustering, with one cluster (Cluster 2) displaying favorable clinical and molecular profiles. A radiomics score was constructed and validated internally and externally, achieving high diagnostic accuracy (area under the curve of 0.98) and independently predicting benign features such as a lower N stage and favorable treatment responses. Transcriptomic analysis revealed immune activation and survival-related gene expression in Cluster 2. The model demonstrated robust performance in stratifying patients for active surveillance and may complement current diagnostic frameworks, offering a precise, noninvasive tool to guide clinical decision-making.<\/jats:p>","DOI":"10.1126\/sciadv.adv6697","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T17:58:38Z","timestamp":1756490318000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Radiotranscriptomics in papillary thyroid carcinoma complement current noninvasive risk stratification system"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4205-3568","authenticated-orcid":true,"given":"Dong Hyun","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Open NBI Convergence Technology Research Laboratory, Yonsei University College of Medicine, Seoul 03722, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9989-3555","authenticated-orcid":true,"given":"Eunjung","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Mathematics and Computing (Computational Science and Engineering), Yonsei University, Seoul 03722, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2100-3513","authenticated-orcid":true,"given":"Jung Hyun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul 03722, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9564-450X","authenticated-orcid":true,"given":"Eun Gyeong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Open NBI Convergence Technology Research Laboratory, Yonsei University College of Medicine, Seoul 03722, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2634-8844","authenticated-orcid":true,"given":"Sunmi","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Open NBI Convergence Technology Research Laboratory, Yonsei University College of Medicine, Seoul 03722, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwa Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Open NBI Convergence Technology Research Laboratory, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9782-0432","authenticated-orcid":true,"given":"Joon","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yongin Severance Hospital, Gyeonggi-do 16995, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7848-3709","authenticated-orcid":true,"given":"Cho Rok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yongin Severance Hospital, Gyeonggi-do 16995, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5687-7237","authenticated-orcid":true,"given":"Kyunghwa","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul 03722, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4090-0049","authenticated-orcid":true,"given":"Jandee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Open NBI Convergence Technology Research Laboratory, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6212-1495","authenticated-orcid":true,"given":"Jin Young","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul 03722, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9926-8389","authenticated-orcid":true,"given":"Young Suk","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Open NBI Convergence Technology Research Laboratory, Yonsei University College of Medicine, Seoul 03722, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0075"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.571421"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0329"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30172-6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1604412"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2022.0325"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae082"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.3875"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1804426"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85271"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.09.050"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02484-7"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.3190"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.180240"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg7125"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-061512-105739"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2654-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-1025"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-6675-0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-2-414"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-4343-6"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1211"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26343-3"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18497-3"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2019.07.018"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/1533033820969451"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0211"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1454"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.06.002"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1109319"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.915135"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6505"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.5094"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-24-0068"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.19.22691"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-06875-w"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.763897"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0354"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2010.11.2.149"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015151169"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1080\/17446651.2020.1707078"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0330"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.859461"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15384"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad236"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.09.043"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30180-2"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2022.06.010"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015142470"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4072"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.231481"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.178.3.1780687"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110206"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2164"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017171240"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0506-500"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096801"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1001138"},{"key":"e_1_3_2_64_2","first-page":"011650","author":"Nicorici D.","year":"2014","unstructured":"D. Nicorici, M. \u015eatalan, H. Edgren, S. Kangaspeska, A. Murum\u00e4gi, O. Kallioniemi, S. Virtanen, O. Kilkku, FusionCatcher \u2212 A tool for finding somatic fusion genes in paired-end RNA-sequencing data. bioRxiv, 011650 (2014).","journal-title":"bioRxiv"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.257246.119"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz430"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adv6697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T17:58:43Z","timestamp":1756490323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adv6697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":65,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2025,8,29]]}},"alternative-id":["10.1126\/sciadv.adv6697"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adv6697","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]},"assertion":[{"value":"2025-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadv6697"}}