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NF-\u03baB activation stabilizes PLAC8 in the cytosol, disrupting autophagy by allowing PLAC8 to colocalize with LC3B instead of LAMP1. Silencing NF-\u03baB down-regulates PLAC8 and its survival function while inhibiting NF-\u03baB or PLAC8, which restores autophagy and decreases tumor growth in xenograft models. In addition, targeting BCL-xL confirmed this signaling pathway. The findings suggest that sustained NF-\u03baB activation regulates PLAC8 and highlights the NF-\u03baB\u2013PLAC8\u2013BCL-xL axis as a potential target for early detection and therapies in metal-induced prostate cancer.<\/jats:p>","DOI":"10.1126\/sciadv.adv8640","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T17:58:28Z","timestamp":1749837508000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":6,"title":["Interaction between NF-\u03baB and PLAC8 impairs autophagy providing a survival advantage to prostate cells transformed by cadmium"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4881-9894","authenticated-orcid":true,"given":"Vaibhav","family":"Shukla","sequence":"first","affiliation":[{"name":"College of Pharmacy, Texas A&amp;M University, College Station, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2909-5755","authenticated-orcid":true,"given":"Ashish","family":"Tyagi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Texas A&amp;M University, College Station, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balaji","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Texas A&amp;M University, College Station, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-3612","authenticated-orcid":true,"given":"Bhawna","family":"Tyagi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Texas A&amp;M University, College Station, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4771-7223","authenticated-orcid":true,"given":"Balpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Texas A&amp;M University, College Station, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0805-1151","authenticated-orcid":true,"given":"Thulasidharan Nair","family":"Devanarayanan","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Texas A&amp;M University, College Station, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh","family":"Kolluru","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Louisville, Louisville, KY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murali","family":"K. 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