{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T01:47:08Z","timestamp":1782006428260,"version":"3.54.5"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"27","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,7,4]]},"abstract":"<jats:p>\n            COVID-19 continues causing substantial mortality despite existing FDA-approved COVID-19 vaccines. An effective COVID-19 vaccine providing durable immunity with minimal reactogenicity is needed. CVXGA1, a PIV5-based intranasal COVID-19 vaccine expressing the Spike (S) protein of SARS-CoV-2, was evaluated in this phase 1 study in adults and teens. CVXGA1 was well tolerated without serious adverse events (AEs) or fever reported. Solicited local and systemic AEs were mostly mild. CVXGA1 elicited S-specific serum and mucosal antibodies and CD8\n            <jats:sup>+<\/jats:sup>\n            cytotoxic T lymphocyte responses in all groups. Significantly lower rates of symptomatic COVID-19 infection were reported in groups receiving high-dose CVXGA1 (HD) compared to that in the group receiving low-dose CVXGA1 (LD) during the SARS-CoV-2 delta and omicron waves. The data indicate that CVXGA1 is a potentially effective intranasal COVID-19 vaccine that is immunogenic with minimal reactogenicity.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adw0896","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T13:58:27Z","timestamp":1751637507000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":11,"title":["Safety and immunogenicity of intranasal parainfluenza virus type 5 (PIV5)\u2013vectored COVID-19 vaccine in adults and teens in an open-label phase 1 trial"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5393-9511","authenticated-orcid":true,"given":"Paul","family":"Spearman","sequence":"first","affiliation":[{"name":"Infectious Diseases, Cincinnati Children\u2019s Hospital and University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0574-2604","authenticated-orcid":true,"given":"Hong","family":"Jin","sequence":"additional","affiliation":[{"name":"CyanVac LLC, 111 Riverbend Rd, Athens, GA 30602, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-8400","authenticated-orcid":true,"given":"Peng","family":"Xiao","sequence":"additional","affiliation":[{"name":"New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0568-7396","authenticated-orcid":true,"given":"Kristeene","family":"Knopp","sequence":"additional","affiliation":[{"name":"CyanVac LLC, 111 Riverbend Rd, Athens, GA 30602, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Radziewicz","sequence":"additional","affiliation":[{"name":"CyanVac LLC, 111 Riverbend Rd, Athens, GA 30602, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8817-4602","authenticated-orcid":true,"given":"Marinka","family":"Tellier","sequence":"additional","affiliation":[{"name":"CyanVac LLC, 111 Riverbend Rd, Athens, GA 30602, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5034-9727","authenticated-orcid":true,"given":"Sasha E.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, WA 98109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan J.","family":"Berube","sequence":"additional","affiliation":[{"name":"Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, WA 98109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA 30604, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8967-2328","authenticated-orcid":true,"given":"Jamie","family":"Kidd","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Cincinnati Children\u2019s Hospital and University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7503-1747","authenticated-orcid":true,"given":"Karnail","family":"Singh","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Cincinnati Children\u2019s Hospital and University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Li","sequence":"additional","affiliation":[{"name":"CyanVac LLC, 111 Riverbend Rd, Athens, GA 30602, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Gingerich","sequence":"additional","affiliation":[{"name":"CyanVac LLC, 111 Riverbend Rd, Athens, GA 30602, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3330-8456","authenticated-orcid":true,"given":"Samuel","family":"Wu","sequence":"additional","affiliation":[{"name":"CyanVac LLC, 111 Riverbend Rd, Athens, GA 30602, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3077-5523","authenticated-orcid":true,"given":"Susan P.","family":"John","sequence":"additional","affiliation":[{"name":"New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-5352","authenticated-orcid":true,"given":"Angela","family":"Branche","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Disease Division, University of Rochester, Rochester NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann R.","family":"Falsey","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Disease Division, University of Rochester, Rochester NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhea","family":"Coler","sequence":"additional","affiliation":[{"name":"Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, WA 98109, USA."},{"name":"Department of Global Health and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7790-2008","authenticated-orcid":true,"given":"Francois J.","family":"Villinger","sequence":"additional","affiliation":[{"name":"New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8336-7171","authenticated-orcid":true,"given":"Biao","family":"He","sequence":"additional","affiliation":[{"name":"CyanVac LLC, 111 Riverbend Rd, Athens, GA 30602, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2109072"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.2598"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01583-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00152-0"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid3006.231285"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg9857"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2209651"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103841"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80200-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00554-20"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.03.049"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","unstructured":"A. C. Beavis Z. Li K. Briggs M. C. Huertas-Diaz E. R. Wrobel M. Najera D. An N. Orr-Burks J. Murray P. Patil J. Huang J. Mousa L. Hao T. Y. Hsiang M. Gale S. B. Harvey S. M. Tompkins R. J. Hogan E. R. Lafontaine H. Jin B. He Efficacy of parainfluenza virus 5 (PIV5)-vectored intranasal COVID-19 vaccine as a single dose vaccine and as a booster against SARS-CoV-2 variants. bioRxiv 495215 [Preprint] (2022). https:\/\/doi.org\/10.1101\/2022.06.07.495215.","DOI":"10.1101\/2022.06.07.495215"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abi5246"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj7611"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1503885112"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7148e1"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39053-9"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2165\/11206860-000000000-00000"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00414-16"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir436"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00087-X"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00396-0"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00131-X"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","unstructured":"C. Singh S. Verma P. Reddy M. S. Diamond D. T. Curiel C. Patel M. K. Jain S. V. Redkar A. S. Bhate V. Gundappa R. Konatham L. Toppo A. C. Joshi J. S. Kushwah A. P. Singh S. Gaidhane K. S. Vadrevu and BBV154 Study Group Immunogenicity and tolerability of BBV154 (iNCOVACC) an intranasal SARS-CoV-2 vaccine compared with intramuscular Covaxin in healthy adults: A randomised open-label phase 3 clinical trial (2023); http:\/\/dx.doi.org\/10.2139\/ssrn.4342771.","DOI":"10.2139\/ssrn.4342771"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104298"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-023-00662-6"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050144"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2021.113160"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adw0896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T13:52:18Z","timestamp":1752673938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adw0896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":28,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2025,7,4]]}},"alternative-id":["10.1126\/sciadv.adw0896"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adw0896","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,4]]},"assertion":[{"value":"2025-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadw0896"}}