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The system comprises a flexible honeycomb ultrasonic array patch, a flexible printed circuit, and an interactive terminal control system to facilitate the treatment process. Our results demonstrate that the system effectively reduces amyloid proteins in the brain, improves cognitive function in a familial Alzheimer\u2019s disease (FAD) mouse model, enhances microglial phagocytosis of amyloid-\u03b2 plaques, and shifts microglia polarization from M1 to M2. These changes contribute to a mitigated inflammatory environment in the brain. This innovative approach may pave the way for noninvasive, personalized treatments for AD, potentially transforming therapeutic strategies in neurodegenerative disorders.<\/jats:p>","DOI":"10.1126\/sciadv.adw1732","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T17:59:27Z","timestamp":1753898367000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":16,"title":["A wearable spatiotemporal controllable ultrasonic device with amyloid-\u03b2 disaggregation for continuous Alzheimer\u2019s disease therapy"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7826-0166","authenticated-orcid":true,"given":"Faxing","family":"Zou","sequence":"first","affiliation":[{"name":"Institute for Advanced Study (IAS), Shenzhen University, Shenzhen, Guangdong 518060, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6118-665X","authenticated-orcid":true,"given":"Yibiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Longgang Central Hospital of Shenzhen, Shenzhen 518116, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9867-094X","authenticated-orcid":true,"given":"Yong","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute for Advanced Study (IAS), Shenzhen University, Shenzhen, Guangdong 518060, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4037-2856","authenticated-orcid":true,"given":"Tailin","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute for Advanced Study (IAS), Shenzhen University, Shenzhen, Guangdong 518060, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37304-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.040"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_3_2_6_2","first-page":"148","article-title":"Amyloid \u03b2-based therapy for Alzheimer\u2019s disease: Challenges, successes and future","volume":"8","author":"Zhang Y.","year":"2023","unstructured":"Y. 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