{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:15:57Z","timestamp":1787994957872,"version":"build-2784847793"},"reference-count":116,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"38","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,9,19]]},"abstract":"<jats:p>\n            Adipocyte hypertrophy during obesity triggers chronic inflammation, leading to metabolic disorders. However, the role of adipocyte-specific inflammatory signaling in metabolic syndrome remains unclear. The linear ubiquitin chain assembly complex, LUBAC, is an E3-ligase that generates nondegradative linear ubiquitination (Lin-Ub). LUBAC regulates NF-\u03baB\/MAPK-driven inflammation and prevents cell death triggered by immune receptors like TNF receptor-1. Here, we show that mice lacking HOIP, the Lin-E3 ligase catalytic subunit of LUBAC, in adipocytes (\n            <jats:italic toggle=\"yes\">\n              Hoip\n              <jats:sup>A-KO<\/jats:sup>\n            <\/jats:italic>\n            ) display lipodystrophy and heightened susceptibility to obesity-induced metabolic syndrome, particularly metabolic dysfunction-associated steatotic liver disease (MASLD). Mechanistically, loss of HOIP attenuates TNF-induced NF-\u03baB activation and promotes cell death in human adipocytes. Inhibiting caspase-8\u2013mediated cell death is sufficient to prevent lipodystrophy and MASLD in\n            <jats:italic toggle=\"yes\">\n              Hoip\n              <jats:sup>A-KO<\/jats:sup>\n            <\/jats:italic>\n            obese mice. HOIP expression in adipose tissue positively correlates with metabolic fitness in obese individuals. Overall, our findings reveal a fundamental developmental role for Lin-Ub in adipocytes by mitigating cell death\u2013driven adipose tissue inflammation and protecting against obesity-related metabolic syndrome.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adw2539","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T17:59:22Z","timestamp":1758131962000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-203X","authenticated-orcid":true,"given":"Ximena","family":"Hildebrandt","sequence":"first","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Department of Translational Genomics, Faculty of Medicine, University of Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4748-8950","authenticated-orcid":true,"given":"\u00d6nay","family":"Veli","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Department of Translational Genomics, Faculty of Medicine, University of Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7870-5555","authenticated-orcid":true,"given":"Armel","family":"Hyoubi","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Department of Translational Genomics, Faculty of Medicine, University of Cologne, Cologne, Germany."},{"name":"Department of Genome Editing, Institute of Biomedical Genetics (IBMG), University of Stuttgart, Stuttgart, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9237-6132","authenticated-orcid":true,"given":"Julia","family":"Zinngrebe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8768-3232","authenticated-orcid":true,"given":"Ali T.","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Bioinformatics Core Facility, CECAD Research Center, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4279-4205","authenticated-orcid":true,"given":"Julian","family":"Rodefeld","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Medical Department III\u2013Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig 04103, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3258-3397","authenticated-orcid":true,"given":"Anne","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum M\u00fcnchen at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3657-7376","authenticated-orcid":true,"given":"Liane","family":"Gardeweg","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Department of Translational Genomics, Faculty of Medicine, University of Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6665-4634","authenticated-orcid":true,"given":"\u00d6yk\u00fc","family":"Kaya","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7433-671X","authenticated-orcid":true,"given":"Elena","family":"Wagner","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Department of Cardiology, Clinic III for Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8664-2562","authenticated-orcid":true,"given":"Andreas","family":"Lindhorst","sequence":"additional","affiliation":[{"name":"Institute of Anatomie, Universit\u00e4t Leipzig, Leipzig, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5548-9681","authenticated-orcid":true,"given":"Matea","family":"Poggenberg","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Department of Translational Genomics, Faculty of Medicine, University of Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8589-5568","authenticated-orcid":true,"given":"Jo\u00eblle","family":"Dimmler","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Department of Translational Genomics, Faculty of Medicine, University of Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5101-7940","authenticated-orcid":true,"given":"Jutta","family":"Schillings","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Department of Translational Genomics, Faculty of Medicine, University of Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3436-4945","authenticated-orcid":true,"given":"Pegi","family":"Koci","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Department of Translational Genomics, Faculty of Medicine, University of Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9420-7339","authenticated-orcid":true,"given":"Francesca","family":"Bonechi","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Valdez","family":"Capuccino","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Department of Translational Genomics, Faculty of Medicine, University of Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1577-8565","authenticated-orcid":true,"given":"Christine","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Genome Instability, Inflammation and Cell death Laboratory, Institute of Biochemistry I, Medical Faculty, University of Cologne, 50931 Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4257-9404","authenticated-orcid":true,"given":"Konstantinos","family":"Kelepouras","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Genome Instability, Inflammation and Cell death Laboratory, Institute of Biochemistry I, Medical Faculty, University of Cologne, 50931 Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5160-4571","authenticated-orcid":true,"given":"Adhideb","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Institute of Food, Nutrition and Health, ETH, Zurich 8092 Schwerzenbach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3360-5455","authenticated-orcid":true,"given":"Falko","family":"No\u00e9","sequence":"additional","affiliation":[{"name":"Institute of Food, Nutrition and Health, ETH, Zurich 8092 Schwerzenbach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3862-6805","authenticated-orcid":true,"given":"Christian","family":"Wolfrum","sequence":"additional","affiliation":[{"name":"Institute of Food, Nutrition and Health, ETH, Zurich 8092 Schwerzenbach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Singer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie, Hepatologie und Infektiologie, D\u00fcsseldorf, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2662-1281","authenticated-orcid":true,"given":"Gianmaria","family":"Liccardi","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Genome Instability, Inflammation and Cell death Laboratory, Institute of Biochemistry I, Medical Faculty, University of Cologne, 50931 Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6288-8821","authenticated-orcid":true,"given":"Tom","family":"Luedde","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie, Hepatologie und Infektiologie, D\u00fcsseldorf, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8408-3063","authenticated-orcid":true,"given":"Aslihan","family":"Yavas","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie, Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0695-3403","authenticated-orcid":true,"given":"Ahmed","family":"Ghallab","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystr. 67, 44139, Dortmund, Germany."},{"name":"Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan G.","family":"Hengstler","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystr. 67, 44139, Dortmund, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-7757","authenticated-orcid":true,"given":"Philipp","family":"Antczak","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Department II of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0792-5394","authenticated-orcid":true,"given":"Martin","family":"Gericke","sequence":"additional","affiliation":[{"name":"Institute of Anatomie, Universit\u00e4t Leipzig, Leipzig, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-2031","authenticated-orcid":true,"given":"Holger","family":"Winkels","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Department of Cardiology, Clinic III for Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0208-2065","authenticated-orcid":true,"given":"Matthias","family":"Bl\u00fcher","sequence":"additional","affiliation":[{"name":"Medical Department III\u2013Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig 04103, Germany."},{"name":"Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum M\u00fcnchen at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6312-4591","authenticated-orcid":true,"given":"Henning","family":"Walczak","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Institute of Biochemistry I, Medical Faculty, University of Cologne, 50931 Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0346-4340","authenticated-orcid":true,"given":"Alessandro","family":"Annibaldi","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3402-9840","authenticated-orcid":true,"given":"Pamela","family":"Fischer-Posovszky","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany."},{"name":"German Center for Child and Adolescent Health (DZKJ), partner site Ulm, Ulm, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-5852","authenticated-orcid":true,"given":"Nieves","family":"Peltzer","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany."},{"name":"Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany."},{"name":"Department of Translational Genomics, Faculty of Medicine, University of Cologne, Cologne, Germany."},{"name":"Department of Genome Editing, Institute of Biomedical Genetics (IBMG), University of Stuttgart, Stuttgart, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21363"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.08.018"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-014-9301-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1074"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.02.038"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.01.024"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500294-JLR200"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.074252"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-022-01062-4"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2017.01.006"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/db22-1033"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-00279-2"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11869"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"e0149677","DOI":"10.1371\/journal.pone.0149677","article-title":"Blocking nuclear factor-kappa B protects against diet-induced hepatic steatosis and insulin resistance in mice","volume":"11","author":"Zeng T.","year":"2016","unstructured":"T. Zeng, J. Zhou, L. He, J. Zheng, L. Chen, C. Wu, W. Xia, Blocking nuclear factor-kappa B protects against diet-induced hepatic steatosis and insulin resistance in mice. PLOS ONE 11, e0149677 (2016).","journal-title":"PLOS ONE"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505924"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250256"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32756"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.4.9.2030"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1262"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321767"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09816"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.10.013"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2009.144"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09814"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09815"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.170026"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2023.05.007"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03464"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29074"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.111"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0064-8"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06155-8"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.08.066"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13353"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.184"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-024-01355-w"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2457"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01817-w"},{"key":"e_1_3_2_40_2","first-page":"1436","article-title":"Cell death-related ubiquitin modifications in inflammatory syndromes: From mice to men","volume":"10","author":"Peltzer N.","year":"2022","unstructured":"N. Peltzer, A. Annibaldi, Cell death-related ubiquitin modifications in inflammatory syndromes: From mice to men. Biomedicine 10, 1436 (2022).","journal-title":"Biomedicine"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20141130"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00399"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.208512"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.033"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2016.02.066"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1753"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05875.x"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.977485"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03872-9"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aba4448"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0237"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051442"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.947147"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005010106"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801520"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2015.198"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.20900\/immunometab20220003"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3159"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.11.051"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2012.01.009"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/90984"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1920004117"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvt079"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2023.10.006"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.030874"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/cdn\/nzaa063_103"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1156"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.10.068"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.07.032"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1770-6"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.04.002"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M038638"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14740"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.140180"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.02.003"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052813"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202302446"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.05.017"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.05.001"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-024-00508-3"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16425"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15096"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.6.3469"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(74)90116-0"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00414-7"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79743"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101286"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.343"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.12.053"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep14841"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1159\/000494295"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa004"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00586.2009"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-5066-2"},{"key":"e_1_3_2_95_2","first-page":"2806","article-title":"Laminin \u03b14 expression in human adipose tissue depots and its association with obesity and obesity related traits","volume":"11","author":"Hagemann T.","year":"2023","unstructured":"T. Hagemann, P. Czechowski, A. Ghosh, W. Sun, H. Dong, F. No\u00e9, C. Wolfrum, M. Bl\u00fcher, A. Hoffmann, Laminin \u03b14 expression in human adipose tissue depots and its association with obesity and obesity related traits. Biomedicine 11, 2806 (2023).","journal-title":"Biomedicine"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3519"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0439-x"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177459"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3820"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw354"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2375"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4197"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz369"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty926"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-023-02014-7"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"e_1_3_2_110_2","unstructured":"MSigDB gene sets R package; https:\/\/igordot.github.io\/msigdbr\/."},{"key":"e_1_3_2_111_2","unstructured":"H. Patel P. Ewels J. Manning M. U. Garcia A. Peltzer R. Hammar\u00e9n O. Botvinnik A. Talbot G. Sturm N.-C. Bot M. Zepper D. Moreno P. Vemuri M. Binzer-Panchal E. Greenberg silviamorins L. Pantano R. Syme G. Kelly F. Hanssen J. A. Fellows Yates J. Espinosa-Carrasco rfenouil L. Zappia C. Cheshire E. Miller marchoeppner P. Zhou S. Guinchard G. Gabernet Nf-Core\/rnaseq: Nf-Core\/rnaseq v3.18.0\u2013Lithium Lynx (Zenodo 2024); https:\/\/zenodo.org\/records\/14537300)."},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-10-r106"},{"key":"e_1_3_2_113_2","unstructured":"R Core Team R A Language and Environment for Statistical Computing. (R Foundation for Statistical Computing 2021); www.scirp.org\/reference\/referencespapers?referenceid=3131254."},{"key":"e_1_3_2_114_2","doi-asserted-by":"crossref","unstructured":"H. Wickham Ggplot2: Elegant Graphics for Data Analysis (Springer International Publishing ed. 2 2016).","DOI":"10.1007\/978-3-319-24277-4_9"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.10.035"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-487-6_1"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adw2539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:25:53Z","timestamp":1758828353000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adw2539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":116,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2025,9,19]]}},"alternative-id":["10.1126\/sciadv.adw2539"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adw2539","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,19]]},"assertion":[{"value":"2025-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadw2539"}}