{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:37:09Z","timestamp":1792798629574,"version":"4.5.0"},"reference-count":54,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"51","funder":[{"DOI":"10.13039\/501100002648","name":"Catholic University of Korea","doi-asserted-by":"publisher","award":["HI22C1314"],"award-info":[{"award-number":["HI22C1314"]}],"id":[{"id":"10.13039\/501100002648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002648","name":"Catholic University of Korea","doi-asserted-by":"publisher","award":["NRF-2021R1C1C2004688"],"award-info":[{"award-number":["NRF-2021R1C1C2004688"]}],"id":[{"id":"10.13039\/501100002648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013128","name":"Korea Technology and Information Promotion Agency for SMEs","doi-asserted-by":"publisher","award":["RS-2023-00302955"],"award-info":[{"award-number":["RS-2023-00302955"]}],"id":[{"id":"10.13039\/501100013128","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean Fund for Regenerative Medicine funded by Ministry of Science and ICT, and Ministry of Health and Welfare","award":["RS-2022-00165160"],"award-info":[{"award-number":["RS-2022-00165160"]}],"id":[{"id":"https:\/\/ror.org\/00vxgjw72","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Research Foundation of Korea (NRF) from the Korean government","award":["NRF-2021R1C1C2004688"],"award-info":[{"award-number":["NRF-2021R1C1C2004688"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"crossref"}]},{"name":"YiPSCELL","award":["RS-2022-00165160"],"award-info":[{"award-number":["RS-2022-00165160"]}]},{"name":"YiPSCELL","award":["RS-2023-00302955"],"award-info":[{"award-number":["RS-2023-00302955"]}]},{"DOI":"10.13039\/501100020621","name":"Seoul St.Mary's hospital","doi-asserted-by":"crossref","award":["RS-2025-16068032"],"award-info":[{"award-number":["RS-2025-16068032"]}],"id":[{"id":"10.13039\/501100020621","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,12,19]]},"abstract":"<jats:p>Induced pluripotent stem cell (iPSC)\u2013derived chondrogenic tissues represent a promising alternative for treating cartilage defects in chronic degenerative joint conditions such as osteoarthritis (OA). Cartilage tissue has limited self-repair capacity, and although allogeneic transplantation has potential, a less invasive delivery method could enhance the efficacy of cell-based therapies. The aim of this study was to develop iPSC-derived \u201cminimal injectable unit\u201d chondrogenic micropellets (MIUChons) for delivery via intra-articular injections for OA therapy. To create transplantable allogeneic cartilage tissue, we optimized good manufacturing practice or clinical-grade production of iPSC-derived injectable chondrogenic spheroids and tested them in OA animal models. MIUChons were delivered to damaged cartilage through a single injection. In vivo and in vitro analyses demonstrated that MIUChon treatment effectively reduced cartilage degeneration and deterioration. In addition, injecting MIUChons into the intra-articular cavity improved arthritis symptoms. Overall, MIUChons offer a strategy for treating cartilage deterioration via intra-articular injection in patients with OA.<\/jats:p>","DOI":"10.1126\/sciadv.adw4911","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T18:59:52Z","timestamp":1765997992000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Clinical-grade iPSC-derived chondrogenic micropellets for treating advanced cartilage defects"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4583-3455","authenticated-orcid":true,"given":"Yoojun","family":"Nam","sequence":"first","affiliation":[{"name":"YiPSCELL Inc., L2 Omnibus Park, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea."},{"name":"Department of Biohealth Regulatory Science, Sungkyunkwan University, Suwon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4859-1351","authenticated-orcid":true,"given":"Narae","family":"Park","sequence":"additional","affiliation":[{"name":"YiPSCELL Inc., L2 Omnibus Park, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea."},{"name":"Department of Biohealth Regulatory Science, Sungkyunkwan University, Suwon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9187-6722","authenticated-orcid":true,"given":"Jinhyeok","family":"Choi","sequence":"additional","affiliation":[{"name":"YiPSCELL Inc., L2 Omnibus Park, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6607-7540","authenticated-orcid":true,"given":"Kijun","family":"Lee","sequence":"additional","affiliation":[{"name":"YiPSCELL Inc., L2 Omnibus Park, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6580-7065","authenticated-orcid":true,"given":"Si Hwa","family":"Choi","sequence":"additional","affiliation":[{"name":"YiPSCELL Inc., L2 Omnibus Park, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7793-4464","authenticated-orcid":true,"given":"Jang-Woon","family":"Kim","sequence":"additional","affiliation":[{"name":"CiSTEM Laboratory, Catholic iPSC Research Center, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1331-3463","authenticated-orcid":true,"given":"SeonJu","family":"Choi","sequence":"additional","affiliation":[{"name":"YiPSCELL Inc., L2 Omnibus Park, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5030-1248","authenticated-orcid":true,"given":"Chang Pyo","family":"Hong","sequence":"additional","affiliation":[{"name":"YiPSCELL Inc., L2 Omnibus Park, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6873-6629","authenticated-orcid":true,"given":"Jennifer","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary\u2019s Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6909-0919","authenticated-orcid":true,"given":"Joon-Yong","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2373-7024","authenticated-orcid":true,"given":"Soon Nam","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9541-3075","authenticated-orcid":true,"given":"Yeri Alice","family":"Rim","sequence":"additional","affiliation":[{"name":"CiSTEM Laboratory, Catholic iPSC Research Center, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1381-5466","authenticated-orcid":true,"given":"Ji Hyeon","family":"Ju","sequence":"additional","affiliation":[{"name":"YiPSCELL Inc., L2 Omnibus Park, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea."},{"name":"CiSTEM Laboratory, Catholic iPSC Research Center, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea."},{"name":"Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary\u2019s Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8490489"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718794864"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.05.052"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030582"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S410277"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2024.101972"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-010423-095636"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08771-z"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01515-1"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2938-2_6"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030529"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4524"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1140717"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00270"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72038-y"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0477-6"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-018-0075-8"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2016.06.010"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.01.009"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2931"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-014-9581-5"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2023.06.003"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.04.008"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-022-00239-4"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223227"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224420"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1460416"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.05.005"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.12.003"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01330-w"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B3.15552"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000171916.40245.5d"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-012-0175-9"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.1998.4.415"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2013.05.008"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15376-8"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9432616"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8090969"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2022.11.001"},{"key":"e_1_3_2_42_2","first-page":"5249","article-title":"Fibulin-5 protects the extracellular matrix of chondrocytes by inhibiting the Wnt\/\u03b2-catenin signaling pathway and relieves osteoarthritis","volume":"24","author":"Gao J. B.","year":"2020","unstructured":"J. B. Gao, L. Lin, X. Q. Men, J. B. Zhao, M. H. Zhang, L. P. Jin, S. J. Gao, S. Q. Zhao, J. T. Dong, Fibulin-5 protects the extracellular matrix of chondrocytes by inhibiting the Wnt\/\u03b2-catenin signaling pathway and relieves osteoarthritis. Eur. Rev. Med. Pharmacol. Sci. 24, 5249\u20135258 (2020).","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517716641"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.47102\/annals-acadmedsg.V41N11p511"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2022.01.010"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl4222"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.04.009"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2009.09.004"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2021.07.006"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514528671"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2017.11.021"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36408-0"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69641-4"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.2578"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.2705"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adw4911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T19:00:17Z","timestamp":1765998017000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adw4911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":54,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2025,12,19]]}},"alternative-id":["10.1126\/sciadv.adw4911"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adw4911","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"assertion":[{"value":"2025-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadw4911"}}