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Adv."],"published-print":{"date-parts":[[2025,12,19]]},"abstract":"<jats:p>\n                    Sporadic early-onset Alzheimer\u2019s disease (sEOAD) represents a substantial but less-studied subtype of Alzheimer\u2019s disease (AD). Here, we generated a single-nucleus multiome atlas derived from the postmortem prefrontal cortex, entorhinal cortex, and hippocampus of nine individuals with or without sEOAD. Comprehensive analyses were conducted to delineate cell type\u2013specific transcriptomic changes and linked candidate cis\n                    <jats:italic toggle=\"yes\">-<\/jats:italic>\n                    regulatory elements (cCREs) across brain regions. We prioritized eight conservative transcription factors in glial cells in multiple brain regions, including RFX4 in astrocytes and IKZF1 in microglia, which are implicated in regulating sEOAD-associated genes. Moreover, we identified the top 25 altered intercellular signaling between glial cells and neurons, highlighting their regulatory potential on gene expression in receiver cells. We reported 33 cCREs linked to sEOAD-associated genes overlapped with late-onset AD risk loci, and found that, in addition, sEOAD cCREs are enriched for neuropsychiatric disorder risk variants. This atlas helps dissect transcriptional and chromatin dynamics in sEOAD, providing a key resource for AD research.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adw4917","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T18:59:52Z","timestamp":1765997992000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":6,"title":["Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer\u2019s disease"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9193-6319","authenticated-orcid":true,"given":"Andi","family":"Liu","sequence":"first","affiliation":[{"name":"Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA."},{"name":"Department of Epidemiology, Human Genetics and Environmental Sciences, 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Saeys MultiNicheNet: A flexible framework for differential cell-cell communication analysis from multi-sample multi-condition single-cell transcriptomics data. bioRxiv 544751 [Preprint] (2023). 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