{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:19:39Z","timestamp":1788995979204,"version":"build-2803163510"},"reference-count":57,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"31","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    Acute respiratory distress syndrome (ARDS) is a lethal respiratory condition, while effective pharmacological treatments remain elusive. We identified the decreased mechanical capacity and impaired proliferation of alveolar type 2 (AT2) epithelial cells in the inflammatory environment as the primary contributors to respiratory failure of ARDS. A biomimetic, self-adaptive, 7,8-dihydroxyflavone\u2013loaded hollow mesoporous cerium oxide coated with a platelet membrane (HCeO\n                    <jats:italic toggle=\"yes\">\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    -D@PM) was developed for precise ARDS therapy. HCeO\n                    <jats:italic toggle=\"yes\">\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    -D@PM comprises a platelet membrane (PM) shell for targeted delivery to injured lungs and an HCeO\n                    <jats:italic toggle=\"yes\">\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    core, which enables high drug loading, efficient reactive oxygen species (ROS) scavenging, and penetration of the alveolar-capillary barrier. Initially, HCeO\n                    <jats:italic toggle=\"yes\">\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    -D@PM suppresses the inflammation and mitigates the adverse effects of lesions on AT2 cell by scavenging accumulated ROS. It then adaptively releases 7,8-dihydroxyflavone in response to cysteine\u2013aspartic acid protease 3 activation, facilitating AT2 cell proliferation and notably improving survival rates in vivo, offering a promising advancement in the precise treatment of respiratory diseases.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adw5133","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T17:59:27Z","timestamp":1753898367000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":13,"title":["Biomimetic targeted self-adaptive nanodrug for inflammation optimization and AT2 cell modulation in precise ARDS therapy"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5461-023X","authenticated-orcid":true,"given":"Cheng","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education and Key Laboratory of 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