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Adv."],"published-print":{"date-parts":[[2026,2,6]]},"abstract":"<jats:p>\n                    The relationships between chronic exposure to wildfire smoke PM\n                    <jats:sub>2.5<\/jats:sub>\n                    (particulate matter with aerodynamic diameter\u00a0of \u22642.5 \u03bcm) and mortality remain poorly understood, with causal evidence being particularly scarce. In this ecological study, we used a doubly robust method, incorporating flexible generalized propensity score estimation that captured potential nonlinearity and interactions among confounders and relaxed the distribution form assumption for exposure, to estimate the effects of annual exposure to wildfire smoke PM\n                    <jats:sub>2.5<\/jats:sub>\n                    on all-cause and cause-specific mortality in the contiguous United States from 2006 to 2020. We found that wildfire smoke PM\n                    <jats:sub>2.5<\/jats:sub>\n                    was associated with increased mortality rate for all studied outcomes, except for deaths from transport accidents or falls, which served as negative outcome controls. Wildfire smoke PM\n                    <jats:sub>2.5<\/jats:sub>\n                    was responsible for ~24,100 all-cause deaths per year in the contiguous United States. The exposure-response curve for all-cause mortality increased monotonically, with no evidence of a \u201csafe\u201d threshold. Among the six cause-specific outcomes, mortality from neurological disease showed the greatest increase per 0.1 \u03bcg\/m\n                    <jats:sup>3<\/jats:sup>\n                    increase in smoke PM\n                    <jats:sub>2.5<\/jats:sub>\n                    exposure. Our study provided robust evidence for the chronic effect of wildfire smoke PM\n                    <jats:sub>2.5<\/jats:sub>\n                    on mortality, underscoring the urgent need for targeted measures to mitigate the substantial and escalating burden of wildfires.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adw5890","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:58:53Z","timestamp":1770231533000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":5,"title":["Wildfire smoke PM\n                    <sub>2.5<\/sub>\n                    and mortality rate in the contiguous United States: A causal modeling study"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0663-1974","authenticated-orcid":true,"given":"Min","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4771-8813","authenticated-orcid":true,"given":"Edgar","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2852-4477","authenticated-orcid":true,"given":"Alexandra","family":"Shtein","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2192-198X","authenticated-orcid":true,"given":"Adjani A.","family":"Peralta","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA."},{"name":"Amsterdam University College, University of Amsterdam, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5802-1600","authenticated-orcid":true,"given":"Mahdieh","family":"Danesh Yazdi","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA."},{"name":"Program in Public Health, Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4884-657X","authenticated-orcid":true,"given":"Xiao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6168-378X","authenticated-orcid":true,"given":"Joel D.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA."},{"name":"Department of Epidemiology, Harvard T.H. 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