{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:27:29Z","timestamp":1793082449076,"version":"4.5.0"},"reference-count":51,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"39","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,9,26]]},"abstract":"<jats:p>\n                    Glycans regulate cellular function, yet how aging affects the glycocalyx remains unclear. Here, we investigate changes in immune cell glycocalyx with age and find that \u03b12,6-linked sialic acid, a glycan epitope associated with inhibitory signaling, is down-regulated in T cells from old animals. This reduction is tightly correlated with age-associated accumulation of effector T cells, which have little to no \u03b12,6-linked sialic acid. To understand how \u03b12,6-linked sialic acid affects T cell physiology, we generated a mouse model with T cell\u2013specific deletion of sialyltransferase gene\n                    <jats:italic toggle=\"yes\">St6gal1<\/jats:italic>\n                    . The lack of \u03b12,6-linked sialic acid leads to reduced responsiveness in na\u00efve T cells, leading to impaired T cell responses against\n                    <jats:italic toggle=\"yes\">Listeria monocytogenes<\/jats:italic>\n                    infection and tumor growth. PD-1 pathway blockade partially restores\n                    <jats:italic toggle=\"yes\">St6gal1<\/jats:italic>\n                    -deficient T cells\u2019 ability to control tumor growth. These findings suggest that \u03b12,6-linked sialic acid is critical for maintaining long-term T cell responsiveness, and its loss may contribute to decreased T cell function with age.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adw6755","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:58:32Z","timestamp":1758909512000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":5,"title":["Age-related remodeling of the sialoglycans dampens murine CD8\n                    <sup>+<\/sup>\n                    T cell function"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9353-6071","authenticated-orcid":true,"given":"Hanlin","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3807-5329","authenticated-orcid":true,"given":"C. Kimberly","family":"Tsui","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5786-7914","authenticated-orcid":true,"given":"Jesse Garcia","family":"Castillo","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4436-3826","authenticated-orcid":true,"given":"Esther Jeong Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7426-3275","authenticated-orcid":true,"given":"HengChen","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0016-7554","authenticated-orcid":true,"given":"Larry K.","family":"Joe","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Twells","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Alberta, Edmonton, T6G 2G2, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3630-5266","authenticated-orcid":true,"given":"Ellen A.","family":"Robey","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4791-8524","authenticated-orcid":true,"given":"Lara K.","family":"Mahal","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Alberta, Edmonton, T6G 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