{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:18:35Z","timestamp":1781763515428,"version":"3.54.5"},"reference-count":36,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"34","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,8,22]]},"abstract":"\n Papillary thyroid carcinoma (PTC) incidence increased after childhood exposure to radioactive fallout from the Chornobyl accident. We investigated PTC genomic profiles to distinguish radiation-induced versus sporadic oncogenic drivers by modeling dose and molecular characteristics by driver category:\n \n BRAF\n V600E<\/jats:sup>\n <\/jats:italic>\n (\n n<\/jats:italic>\n = 132), RAS mutation (\n n<\/jats:italic>\n = 31), fusions generated from two breakpoints and <20 base pairs (bp) breakpoint gain\/loss (Fusion\n 2B<20bp<\/jats:sup>\n ;\n n<\/jats:italic>\n = 63), or \u22653 breakpoints and \u22651000 bp breakpoint loss (\n n<\/jats:italic>\n = 20). The frequency of Fusion\n 2B<20bp<\/jats:sup>\n -PTC increased with increasing thyroid radiation dose, whereas all others declined. Clonal small deletion counts increased with increasing radiation dose for Fusion\n 2B<20bp<\/jats:sup>\n -PTC (\n P<\/jats:italic>\n = 5.1 \u00d7 10\n \u22124<\/jats:sup>\n ) but not other drivers (\n P<\/jats:italic>\n > 0.08). Clonal clock mutational signatures, marking the age of tumor initiation, were associated with age at the accident for Fusion\n 2B<20bp<\/jats:sup>\n -PTC (\n P<\/jats:italic>\n = 8.2 \u00d7 10\n \u22124<\/jats:sup>\n ) but not other drivers (\n P<\/jats:italic>\n > 0.21). Together, these results support a causal role for ionizing radiation in Fusion\n 2B<20bp<\/jats:sup>\n -PTC as a group but not other drivers.\n <\/jats:p>","DOI":"10.1126\/sciadv.adw7680","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T17:58:56Z","timestamp":1755885536000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":4,"title":["Distinctive molecular features of radiation-induced thyroid cancers"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4164-5625","authenticated-orcid":true,"given":"Danielle M.","family":"Karyadi","sequence":"first","affiliation":[{"name":"Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5119-0236","authenticated-orcid":true,"given":"Tetiana I.","family":"Bogdanova","sequence":"additional","affiliation":[{"name":"Laboratory of Morphology of the Endocrine System, V.P. Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9400-2095","authenticated-orcid":true,"given":"Cato M.","family":"Milder","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6584-005X","authenticated-orcid":true,"given":"Stephen W.","family":"Hartley","sequence":"additional","affiliation":[{"name":"Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5389-6267","authenticated-orcid":true,"given":"Olivia W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2234-0631","authenticated-orcid":true,"given":"Michael","family":"Dean","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7952-379X","authenticated-orcid":true,"given":"Vladimir","family":"Drozdovitch","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8028-0588","authenticated-orcid":true,"given":"Elizabeth K.","family":"Cahoon","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5123-9674","authenticated-orcid":true,"given":"Sergii","family":"Masiuk","sequence":"additional","affiliation":[{"name":"Radiological Protection Laboratory, State Institution National Research Center for Radiation Medicine Hematology and Oncology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9852-0669","authenticated-orcid":true,"given":"Mykola","family":"Chepurny","sequence":"additional","affiliation":[{"name":"Radiological Protection Laboratory, State Institution National Research Center for Radiation Medicine Hematology and Oncology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5138-4532","authenticated-orcid":true,"given":"Liudmyla Yu","family":"Zurnadzhy","sequence":"additional","affiliation":[{"name":"Laboratory of Morphology of the Endocrine System, V.P. Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1411-0257","authenticated-orcid":true,"given":"Vibha","family":"Vij","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6416-4432","authenticated-orcid":true,"given":"Cari M.","family":"Kitahara","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry A.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayle E.","family":"Woloschak","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1575-4748","authenticated-orcid":true,"given":"Dale A.","family":"Ramsden","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7421-0981","authenticated-orcid":true,"given":"Mykola D.","family":"Tronko","sequence":"additional","affiliation":[{"name":"Department of Fundamental and Applied Problems of Endocrinology, V.P. 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