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Using parylene C film for waterproofing and encapsulation, the ultrathin perovskite curved image sensor with the hierarchical mesh design is demonstrated, which conforms to spherical surfaces of different radii while maintaining mechanical stability during deformation. The image sensor exhibits low detection limit (10 nanowatts per square centimeter) and long-term stable dynamic photoresponse. Combining the image sensor with a tunable lens achieves clear images at different distances via simultaneously adjusting both sensor and lens radii. Furthermore, through integrating image sensor with a readout matrix and wireless data collection component, the real-time imaging system is demonstrated with real-time focus-tunable imaging capabilities.<\/jats:p>","DOI":"10.1126\/sciadv.adw7826","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T17:58:46Z","timestamp":1756922326000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":28,"title":["Focus-tunable real-time imaging system based on ultrathin perovskite curved image sensor with hierarchical mesh design"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3793-8422","authenticated-orcid":true,"given":"Zeping","family":"He","sequence":"first","affiliation":[{"name":"CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, P. 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