{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:32:51Z","timestamp":1789410771227,"version":"build-2803163510"},"reference-count":79,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"43","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,10,24]]},"abstract":"<jats:p>\n                    Psoriasis (Pso) is a chronic inflammatory skin disease driven by T helper 17 (T\n                    <jats:sub>H<\/jats:sub>\n                    17) cells, with several clinical subtypes. While self-reactive immune responses have been observed, the role of autoantigens in Pso remains unclear. Using immunopeptidomics, we identified serpin family B member 3 (SERPINB3) and SERPINB4 as candidate autoantigens in Pso skin. In a mouse model, the SERPINB3 ortholog Serpinb3b enhanced inflammation, promoted tissue-resident memory T cells, and skewed immunity toward a T\n                    <jats:sub>H<\/jats:sub>\n                    2 phenotype. In humans, SERPINB3 reactivity was specifically associated with \u201ceczematized psoriasis\u201d (EczPso), a subtype marked by T\n                    <jats:sub>H<\/jats:sub>\n                    2\/T\n                    <jats:sub>H<\/jats:sub>\n                    17 immune signatures. SERPINB3 protein was enriched in EczPso lesions and highly secreted by keratinocytes under combined T\n                    <jats:sub>H<\/jats:sub>\n                    2\/T\n                    <jats:sub>H<\/jats:sub>\n                    17 stimulation. Lesional T cells from EczPso\u2014but not from eczema or classical plaque Pso\u2014proliferated in response to SERPINB3 and induced EczPso-like features in a skin model. Our findings identify SERPINB3 as an autoantigen driving a distinct Pso subtype, supporting more precise diagnosis and therapy.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adx0637","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:59:42Z","timestamp":1761155982000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":4,"title":["Immunopeptidome analysis reveals SERPINB3 as an autoantigen driving eczematized psoriasis"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6051-4036","authenticated-orcid":true,"given":"Manja","family":"Jargosch","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany."},{"name":"ZAUM\u2014Center of Allergy and Environment, Technical University of Munich, School of Medicine and Health &amp; Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0840-6826","authenticated-orcid":true,"given":"Jomy","family":"Kuruvila","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-3262","authenticated-orcid":true,"given":"Emanuele","family":"Scala","sequence":"additional","affiliation":[{"name":"Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden."},{"name":"Department of Dermatology and Venereology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Grosch","sequence":"additional","affiliation":[{"name":"ZAUM\u2014Center of Allergy and Environment, Technical University of Munich, School of Medicine and Health &amp; Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1363-6247","authenticated-orcid":true,"given":"Jessica","family":"Eigemann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany."},{"name":"ZAUM\u2014Center of Allergy and Environment, Technical University of Munich, School of Medicine and Health &amp; Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany."},{"name":"Department of Dermatology and Allergy, LMU Hospital, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2797-6867","authenticated-orcid":true,"given":"Sophia","family":"Wasserer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany."},{"name":"ZAUM\u2014Center of Allergy and Environment, Technical University of Munich, School of Medicine and Health &amp; Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3579-2824","authenticated-orcid":true,"given":"Shalva","family":"Lekiashvili","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3292-8850","authenticated-orcid":true,"given":"Nico","family":"Trautwein","sequence":"additional","affiliation":[{"name":"Institute of Immunology, University of T\u00fcbingen, T\u00fcbingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0482-9927","authenticated-orcid":true,"given":"Daniel Johannes","family":"Kowalewski","sequence":"additional","affiliation":[{"name":"Institute of Immunology, University of T\u00fcbingen, T\u00fcbingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"B\u00f6hner","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3762-0498","authenticated-orcid":true,"given":"Yigit","family":"K\u00f6seoglu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany."},{"name":"ZAUM\u2014Center of Allergy and Environment, Technical University of Munich, School of Medicine and Health &amp; Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7447-547X","authenticated-orcid":true,"given":"Christina","family":"Hillig","sequence":"additional","affiliation":[{"name":"Department of Computational Health, Institute of Computational Biology, Helmholtz Munich, Neuherberg, Germany."},{"name":"Department of Mathematics, Technical University of Munich, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6386-7352","authenticated-orcid":true,"given":"Jenny","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany."},{"name":"ZAUM\u2014Center of Allergy and Environment, Technical University of Munich, School of Medicine and Health &amp; Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany."},{"name":"Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1992-2836","authenticated-orcid":true,"given":"Felix","family":"Lauffer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany."},{"name":"ZAUM\u2014Center of Allergy and Environment, Technical University of Munich, School of Medicine and Health &amp; Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany."},{"name":"Department of Dermatology and Allergy, LMU Hospital, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-8084","authenticated-orcid":true,"given":"Carsten B.","family":"Schmidt-Weber","sequence":"additional","affiliation":[{"name":"ZAUM\u2014Center of Allergy and Environment, Technical University of Munich, School of Medicine and Health &amp; Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany."},{"name":"German Center of Lung Research (DZL), Neuherberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0267-5792","authenticated-orcid":true,"given":"Michael P.","family":"Menden","sequence":"additional","affiliation":[{"name":"Department of Computational Health, Institute of Computational Biology, Helmholtz Munich, Neuherberg, Germany."},{"name":"Department of Biochemistry &amp; Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6404-7391","authenticated-orcid":true,"given":"Juliane S.","family":"Walz","sequence":"additional","affiliation":[{"name":"Institute of Immunology, University of T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"Cluster of Excellence iFIT (EXC 2180) \u201cImage-Guided and Functionally Instructed Tumor Therapies\u201d, University of T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site T\u00fcbingen, T\u00fcbingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Kaesler","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Eyerich","sequence":"additional","affiliation":[{"name":"ZAUM\u2014Center of Allergy and Environment, Technical University of Munich, School of Medicine and Health &amp; Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Blank","sequence":"additional","affiliation":[{"name":"ZAUM\u2014Center of Allergy and Environment, Technical University of Munich, School of Medicine and Health &amp; Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1614-2647","authenticated-orcid":true,"given":"Hans-Georg","family":"Rammensee","sequence":"additional","affiliation":[{"name":"Institute of Immunology, University of T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"Cluster of Excellence iFIT (EXC 2180) \u201cImage-Guided and Functionally Instructed Tumor Therapies\u201d, University of T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site T\u00fcbingen, T\u00fcbingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5352-5105","authenticated-orcid":true,"given":"Tilo","family":"Biedermann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0094-2674","authenticated-orcid":true,"given":"Kilian","family":"Eyerich","sequence":"additional","affiliation":[{"name":"Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden."},{"name":"Department of Dermatology and Venereology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-4205","authenticated-orcid":true,"given":"Zsuzsanna","family":"Kurgyis","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9827-4979","authenticated-orcid":true,"given":"Lena K.","family":"Freudenmann","sequence":"additional","affiliation":[{"name":"Institute of Immunology, University of T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"Cluster of Excellence iFIT (EXC 2180) \u201cImage-Guided and Functionally Instructed Tumor Therapies\u201d, University of T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site T\u00fcbingen, T\u00fcbingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7409-7883","authenticated-orcid":true,"given":"Natalie","family":"Garzorz-Stark","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany."},{"name":"Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden."},{"name":"Department of Dermatology and Venereology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214065"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.339"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08307.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001711"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32549-6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.12.036"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.59"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/2589977513666210707114520"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314258"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109997"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.03.037"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109017"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/503821"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.01.001"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6621"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151093"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300348"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2016.11.006"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160258"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1695760"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37547-0"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12936"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04839-2"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.09.005"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.009"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.1.27"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(94)90032-9"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(94)90033-7"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1049079"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5782922"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802999"},{"key":"e_1_3_2_33_2","first-page":"445","article-title":"Eczematized psoriasis\u2014A frequent but often neglected variant of plaque psoriasis","volume":"21","author":"Lauffer F.","year":"2023","unstructured":"F. Lauffer, K. Eyerich, Eczematized psoriasis\u2014A frequent but often neglected variant of plaque psoriasis. J. Dtsch. Dermatol. Ges. 21, 445\u2013453 (2023).","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13236"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.045"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/ced.15130"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1341632"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13077"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13404"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-002071"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0818-9641.2003.01151.x"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_156572"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.041"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2107725"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay3638"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.21213insight3"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01610.x"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13378"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.042812"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1159\/000217972"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000720)89:4<368::AID-IJC9>3.0.CO;2-6"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35319-w"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.25038"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abf1587"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-013-8353-3"},{"key":"e_1_3_2_56_2","first-page":"132","article-title":"Psoriasis pathogenesis\u2014Pso p27 constitutes a compact structure forming large aggregates","volume":"2","author":"Lysvand H.","year":"2015","unstructured":"H. Lysvand, R. Helland, L. Hagen, G. Slupphaug, O. J. Iversen, Psoriasis pathogenesis\u2014Pso p27 constitutes a compact structure forming large aggregates. Biochem. Biophys. Rep. 2, 132\u2013136 (2015).","journal-title":"Biochem. Biophys. Rep."},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.02.005"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040622"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12634"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.05.066"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2024.04.011"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93396"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20517"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19236"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18846"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-218-6_12"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90296-9"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(85)90333-7"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1982.tb03910.x"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1416389112"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/1044-0305(94)80016-2"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.07.171"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.02.034"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abi4425"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200012)30:12<3591::AID-IMMU3591>3.0.CO;2-J"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2023.100690"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abj3289"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.04.009"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17204-5"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adx0637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:00:10Z","timestamp":1761156010000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adx0637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":79,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2025,10,24]]}},"alternative-id":["10.1126\/sciadv.adx0637"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adx0637","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,24]]},"assertion":[{"value":"2025-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadx0637"}}