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We show diminished glucose leads to light hyperresponsiveness driven by deregulated ON cone bipolar signaling. Transmission of this constitutive signal to RGCs causes ON &gt; OFF signaling imbalance and failure to detect luminance and contrast changes. Our results suggest that the aspartate-malate shuttle in GABAergic amacrine cells metabolizes glucose to \u03b3-aminobutyric acid (GABA), which in turn regulates the ON cone bipolar signal. GABA\n            <jats:sub>A<\/jats:sub>\n            receptor agonists such as Ativan are a widely prescribed first-line therapy for seizures initiated by low brain GABA, and we show that Ativan restores ON cone bipolar cell regulation in RP where retinal GABA is diminished, reestablishing luminance and contrast detection.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adx2050","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T21:26:20Z","timestamp":1753478780000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic regulation of visual acuity"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-5635","authenticated-orcid":true,"given":"Douglas","family":"Emery","sequence":"first","affiliation":[{"name":"Department of Medicine, Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, 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