{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T18:39:47Z","timestamp":1792780787791,"version":"4.5.0"},"reference-count":35,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"43","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072773"],"award-info":[{"award-number":["82072773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573942"],"award-info":[{"award-number":["82573942"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YJ202373"],"award-info":[{"award-number":["YJ202373"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZYYC22001"],"award-info":[{"award-number":["ZYYC22001"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2023YFG0127"],"award-info":[{"award-number":["2023YFG0127"]}]},{"name":"China Foundation for Youth Entrepreneurship and Employment","award":["HX-H2506250"],"award-info":[{"award-number":["HX-H2506250"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,10,23]]},"abstract":"<jats:p>\n                    High-performance brain-computer interfaces (BCIs) rely on stable neural representations, yet brain functional impairments inherently disrupt canonical encoding, creating a fundamental decoding paradox. Conventional data-driven approaches struggle to bridge this gap because of pathological data scarcity and heterogeneity. Here, we propose to leverage healthy neural priors and introduce Pathology-Aware Consensus Training (PACT), a paradigm embedding biophysical constraints into healthy neural recordings to guide neural decoding. In a gesture classification task using high-density electrocorticography from patients with gliomas infiltrating the motor cortex, PACT improved the accuracy by more than 10%, effectively restoring the distorted semantic geometry of motor commands and realigning them with healthy canonical representations (correlation increase:\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u00a0=\u00a00.66 to\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u00a0=\u00a00.94). Mechanistically, PACT induced an emergent \u201cinverse weighting\u201d strategy: The model autonomously suppresses high-power pathological noise while reanchoring spatial attention to functional compensatory regions. This study provides a proof of concept for improving decoding in compromised networks by harnessing healthy neural dynamics, laying the theoretical foundation for future BCI deployments in clinical populations.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adx5564","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T17:58:42Z","timestamp":1792778322000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Biophysically constrained learning from healthy neural priors improves motor decoding in pathological cortical networks"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2856-3203","authenticated-orcid":true,"given":"Yihan","family":"Wu","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Geriatric, West China Hospital of Sichuan University, Chengdu 610017, Sichuan, China."},{"name":"Med-X Center for Manufacturing, Sichuan University, Chengdu 610017, Sichuan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9050-8032","authenticated-orcid":true,"given":"Tao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9598-5882","authenticated-orcid":true,"given":"Siliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0421-2254","authenticated-orcid":true,"given":"Yuxin","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-4706","authenticated-orcid":true,"given":"Qiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Laboratory for Neuro- and Psychophysiology, Department of Neurosciences, KU Leuven, Leuven 3000, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1060-7044","authenticated-orcid":true,"given":"Marc M.","family":"Van Hulle","sequence":"additional","affiliation":[{"name":"Laboratory for Neuro- and Psychophysiology, Department of Neurosciences, KU Leuven, Leuven 3000, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-3334","authenticated-orcid":true,"given":"Yanhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1579-3114","authenticated-orcid":true,"given":"Ning","family":"Jiang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatric, West China Hospital of Sichuan University, Chengdu 610017, Sichuan, China."},{"name":"Med-X Center for Manufacturing, Sichuan University, Chengdu 610017, Sichuan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7883-2697","authenticated-orcid":true,"given":"Dario","family":"Farina","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5724-6541","authenticated-orcid":true,"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6227-0397","authenticated-orcid":true,"given":"Qing","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9915-2108","authenticated-orcid":true,"given":"Jiayuan","family":"He","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatric, West China Hospital of Sichuan University, Chengdu 610017, Sichuan, China."},{"name":"Med-X Center for Manufacturing, Sichuan University, Chengdu 610017, Sichuan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070291"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/416141a"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/35042582"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1097938"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01304-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-023-00714-5"},{"key":"e_1_3_2_8_2","first-page":"161","article-title":"Combining brain-computer interfaces and assistive technologies: State-of-the-art and challenges","volume":"4","author":"Mill\u00e1n J. 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