{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:09:28Z","timestamp":1788228568016,"version":"build-2803163510"},"reference-count":98,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"34","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,8,22]]},"abstract":"<jats:p>\n                    Memory CD8 T cells provide long-lasting immunity, but their developmental origins remain incompletely defined. Growing evidence suggests that functional heterogeneity exists within the na\u00efve T cell pool, shaping lineage potential before antigen stimulation. Here, we identify a subpopulation of na\u00efve CD8 T cells expressing death-associated protein-like 1 (Dapl1) that contains preprogrammed precursors biased toward memory differentiation. The differentiation of these precursors is independent of Dapl1 but relies on the transcription factor B-cell lymphoma\/leukaemia 11b (Bcl11b), resulting in the generation of Dapl1\n                    <jats:sup>+<\/jats:sup>\n                    central memory\u2013like CD8 T cells after infection and stem-like memory cells in cancer. Dapl1\n                    <jats:sup>+<\/jats:sup>\n                    na\u00efve T cells originate among mature thymocytes and gradually appear in the periphery postnatally. Peripheral Dapl1\n                    <jats:sup>+<\/jats:sup>\n                    and Dapl1\n                    <jats:sup>\u2212<\/jats:sup>\n                    populations show limited plasticity, supporting a thymic-imprinting model. These findings reveal a developmentally imprinted subset of na\u00efve CD8 T cells committed to memory fate, uncovering an alternative pathway for memory T cell generation offering new avenues for therapeutic application.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adx5687","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T17:58:56Z","timestamp":1755885536000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":4,"title":["A Dapl1\n                    <sup>+<\/sup>\n                    subpopulation of na\u00efve CD8 T cells is enriched for memory-lineage precursors"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4518-4392","authenticated-orcid":true,"given":"Adam C.","family":"Lynch","sequence":"first","affiliation":[{"name":"Animal Biotechnology and Biomedical Sciences Program, University of Massachusetts, Amherst, MA, USA."},{"name":"Department 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