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The resultant inactivation stabilizes regulators of G protein signaling (RGS4 and RGS5) that ADO normally marks for proteolysis, explaining the drug\u2019s vasodilatory activity and comporting with observations of diminished RGS levels in both clinical preeclampsia and a mouse model thereof. Its inhibition of ADO suggested use of HYZ against glioblastoma (GBM); indeed, a single dose robustly senesces cultured GBM cells. By establishing ADO as a nexus for GBM and preeclampsia and connecting it to HYZ, the results create opportunities for directed tailoring of the old drug for new therapies.<\/jats:p>","DOI":"10.1126\/sciadv.adx7687","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:59:01Z","timestamp":1760551141000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8192-2485","authenticated-orcid":true,"given":"Kyosuke","family":"Shishikura","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0341-2038","authenticated-orcid":true,"given":"Jiasong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The University of Texas at San Antonio, San Antonio, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1311-7166","authenticated-orcid":true,"given":"Yiming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation &amp; 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