{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:50:20Z","timestamp":1790477420792,"version":"4.1.0"},"reference-count":71,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6","funder":[{"DOI":"10.13039\/100017540","name":"NHLBI Division of Intramural Research","doi-asserted-by":"publisher","award":["1ZIAHL006249"],"award-info":[{"award-number":["1ZIAHL006249"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,2,6]]},"abstract":"<jats:p>\n                    Hybrid incompatibility can lead to lethality and sterility of F1 hybrids, promoting speciation. The cell biological basis underlying hybrid incompatibility remains largely unknown, especially in mammals. Here, we found that female hybrids between\n                    <jats:italic toggle=\"yes\">Mus musculus domesticus<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Mus spicilegus<\/jats:italic>\n                    mice are sterile due to the failure of homologous-chromosome separation in oocyte meiosis, producing aneuploid eggs. This nondisjunction phenotype was driven by the mislocalization of the cohesin protector, SGO2, along the chromosome arms instead of its typical centromeric enrichment, resulting in cohesin overprotection. The upstream kinase, BUB1, showed a higher activity in hybrid oocytes, explaining SGO2 mistargeting. Higher BUB1 activity was not observed in mitosis, consistent with viable hybrid mice. Cohesion defects were also evident in hybrid mice from another genus,\n                    <jats:italic toggle=\"yes\">Peromyscus<\/jats:italic>\n                    , wherein cohesin protection is weakened. Defective cohesion in oocytes is a leading cause of reduced fertility. Our work provides evidence that a major cause of human infertility may play a positive role in mammalian speciation.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adx9729","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:58:53Z","timestamp":1770231533000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":5,"title":["Hybrid female sterility due to cohesin protection errors in mouse oocytes"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2859-5910","authenticated-orcid":true,"given":"Warif","family":"El Yakoubi","sequence":"first","affiliation":[{"name":"Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20894, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0984-2058","authenticated-orcid":true,"given":"Bo","family":"Pan","sequence":"additional","affiliation":[{"name":"Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20894, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8406-9333","authenticated-orcid":true,"given":"Takashi","family":"Akera","sequence":"additional","affiliation":[{"name":"Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20894, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2010.04.005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1163934"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.07.037"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"J. Bloom R. Green A. Desai K. Oegema S. A. Rifkin Hybrid incompatibility emerges at the one-cell stage in interspecies Caenorhabditis embryos. bioRxiv 619171 [Preprint] 2024.10.19.619171 (2024). https:\/\/doi.org\/10.1101\/2024.10.19.619171.","DOI":"10.1101\/2024.10.19.619171"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/evo.12747"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1163601"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1133953"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06700-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000458513"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.07.018"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a015792"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00349-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msz140"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.08.054"},{"key":"e_1_3_2_16_2","first-page":"78","article-title":"Le complexe d\u2019esp\u00e8ces du genre Mus en Europe Centrale et Orientale I. G\u00e9n\u00e9tique","volume":"48","author":"Bonhomme J. P. F.","year":"1982","unstructured":"J. P. F. Bonhomme, S. Catalan, P. Gerasimov, P. Orsini, L. Thaler, Le complexe d\u2019esp\u00e8ces du genre Mus en Europe Centrale et Orientale I. G\u00e9n\u00e9tique. Mamm. Biol. 48, 78\u201385 (1982).","journal-title":"Mamm. Biol."},{"key":"e_1_3_2_17_2","first-page":"1","article-title":"Mus spicilegus","author":"Sokolov B. V. E.","year":"1998","unstructured":"B. V. E. Sokolov, E. V. Kotenkova, A. G. Michailenko, Mus spicilegus. J. Mammal. 1\u20136 (1998).","journal-title":"J. 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