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Genomic profiles from 853,005 cells mapped to 12 pancreatic cell types, including multiple exocrine subtypes. \u03b2, Acinar, and other cell types, and related cellular niches, had altered abundance and gene activity in T1D progression, including distinct pathways altered in AAB\n                    <jats:sup>+<\/jats:sup>\n                    compared to T1D. We identified epigenomic drivers of gene activity in T1D and AAB\n                    <jats:sup>+<\/jats:sup>\n                    which, combined with genetic association, revealed causal pathways of T1D risk including antigen presentation in \u03b2 cells. Last, single-cell and spatial profiles together revealed widespread changes in cell-cell signaling in T1D including signals affecting \u03b2 cell regulation. Overall, these results revealed drivers of T1D in the pancreas, which form the basis for therapeutic targets for disease prevention.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.ady0080","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T18:01:02Z","timestamp":1757527262000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":32,"title":["Single-cell multiome and spatial profiling reveals pancreas cell type\u2013specific gene regulatory programs of type 1 diabetes progression"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3219-5773","authenticated-orcid":true,"given":"Rebecca","family":"Melton","sequence":"first","affiliation":[{"name":"Biomedical Sciences Program, University of California San Diego, La Jolla, CA, 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