{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:59:37Z","timestamp":1792022377231,"version":"4.4.0"},"reference-count":72,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"18","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1122506"],"award-info":[{"award-number":["1122506"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1128276"],"award-info":[{"award-number":["1128276"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2002948"],"award-info":[{"award-number":["2002948"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2002948"],"award-info":[{"award-number":["2002948"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Philanthropic donor Andrea Num Glover"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>\n                    Pregnant women infected with influenza A virus (IAV) are at increased risk of severe disease, leading to maternal and fetal complications. Toll-like receptor 7 (TLR7) recognizes single-stranded RNA viruses, including IAV, yet its role in maternal immune responses and pregnancy outcomes during IAV infection is poorly understood. Here, we demonstrate that TLR7-knockout (TLR7\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) pregnant mice showed reduced disease severity, despite similar pulmonary viral titers to wild-type (WT) mice. TLR7\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    dams exhibited distinct pulmonary responses, including reduced lymphocyte infiltration, enhanced neutrophil response, and a shift from type I to type II interferon activity. TLR7 signaling was found to be essential for the development of IAV-induced vascular dysfunction during pregnancy. Offspring from TLR7\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice showed improved body weight and reduced placental and fetal brain inflammation compared to WT counterparts. We provide evidence that TLR7 is a critical mediator of adverse pregnancy outcomes during IAV infection and a potential therapeutic target to reduce maternal and fetal morbidity.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.ady2382","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:58:27Z","timestamp":1777485507000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":2,"title":["TLR7 alters the maternal immune landscape during influenza A infection to increase maternal and fetal morbidity"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3417-1011","authenticated-orcid":true,"given":"Gemma S.","family":"Trollope","sequence":"first","affiliation":[{"name":"Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2162-2939","authenticated-orcid":true,"given":"Mark A.","family":"Miles","sequence":"additional","affiliation":[{"name":"Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5362-8577","authenticated-orcid":true,"given":"Madison","family":"Coward-Smith","sequence":"additional","affiliation":[{"name":"Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Liong","sequence":"additional","affiliation":[{"name":"Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9098-3626","authenticated-orcid":true,"given":"Doug A.","family":"Brooks","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomedical Sciences, College of Health, Adelaide University, North Terrace, Adelaide, South Australia 5001, Australia."},{"name":"Discipline of Histopathology, School of Medicine, Trinity Translational Medicine Institute (TTMI), Trinity College Dublin, Dublin, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"O\u2019Leary","sequence":"additional","affiliation":[{"name":"Discipline of Histopathology, School of Medicine, Trinity Translational Medicine Institute (TTMI), Trinity College Dublin, Dublin, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-7615","authenticated-orcid":true,"given":"Stavros","family":"Selemidis","sequence":"additional","affiliation":[{"name":"Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6131-858X","authenticated-orcid":true,"given":"Stella","family":"Liong","sequence":"additional","affiliation":[{"name":"Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization \u201cInfluenza Update\u201d (2023); 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