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Adv."],"published-print":{"date-parts":[[2026,5,22]]},"abstract":"<jats:p>Conventional prediction models incorporating genetic and clinical factors including breast density underperform in non-European populations. We investigated an artificial intelligence\u2013derived mammogram risk score (MRS), a summary of texture features that captures intrinsic breast-tissue characteristics\u2014the substrate for cancer development. This study leveraged data from two North American screening cohorts totaling &gt;226,000 women, including non-Hispanic white, non-Hispanic Black, East Asian, South Asian, and Indigenous women. MRS distributions showed nonsignificant shifts (and similar SDs) between cohorts and across race and ethnic subgroups. MRS increased with age and was significantly associated with breast cancer risk, with hazard ratios per SD ranging from 2.24 [95% confidence interval (CI), 2.03 to 2.46] to 2.32 (95% CI, 2.25 to 2.39) after age adjustment. Associations remained significant within all subgroups. Calibration was excellent across the racial and ethnic groups and across full-field digital mammograms and tomosynthesis. 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