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Activated with\n                    <jats:italic>N<\/jats:italic>\n                    -iodosuccinimide (NIS)\/trimethylsilyl trifluoromethanesulfonate (TMSOTf), PPAP donors support both O- and N-glycosylation across a broad range of substrates. Guided by density functional theory calculations, their design allows straightforward synthesis through a simple amide coupling reaction, facilitating diverse latent-active transformations and broadening their strategic utility. Furthermore, the distinct reactivity profile of PPAP donors\u2014marked by a clear gap relative to other known donors and orthogonality to many standard activation methods\u2014makes them well suited for modular, one-pot glycosylation strategies. Their ease of synthesis, robust performance in glycosylation, and compatibility with diverse assembly approaches collectively establish PPAP glycosides as powerful tools for the efficient construction of complex carbohydrates.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.ady4274","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T17:58:38Z","timestamp":1753466318000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":10,"title":["<i>Para<\/i>\n                    -(3-phenylpropiolamido)phenyl (PPAP) glycosides: Harnessing\n                    <i>ipso<\/i>\n                    -cyclization\u2013driven glycosylation for strategic flexibility"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9899-3378","authenticated-orcid":true,"given":"Meifang","family":"Yang","sequence":"first","affiliation":[{"name":"Shanghai Frontiers Science Center of TCM Chemical 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