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This system maintains quiescence for extended periods while enabling on-demand, remote-triggered drug release within seconds during emergencies. In a canine (beagle) model, we demonstrate safe gastric residence and functionality for at least 10 weeks, including closed-loop emergency drug delivery modulated by external or onboard biometric sensors for unsupervised symptom detection. At the end of its service life, the capsule can be safely excreted on-demand through the administration of an alkaline solution. These findings establish such a system as a paradigm for emergency-prepared and responsive drug delivery, particularly in vulnerable patient populations.<\/jats:p>","DOI":"10.1126\/sciadv.ady6745","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:58:57Z","timestamp":1761933537000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":15,"title":["A gastric retentive robotic capsule enables emergency-prepared and responsive oral drug delivery in canine models"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6310-6132","authenticated-orcid":true,"given":"Hao","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China."},{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems, School of Pharmacy, 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