{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:59:36Z","timestamp":1791082776963,"version":"4.1.0"},"reference-count":78,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS110672"],"award-info":[{"award-number":["R01NS110672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1RF1NS122880, NS133979 and AG085401"],"award-info":[{"award-number":["1RF1NS122880, NS133979 and AG085401"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1RF1NS122880, NS133979 and AG085401"],"award-info":[{"award-number":["1RF1NS122880, NS133979 and AG085401"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R0107418"],"award-info":[{"award-number":["R0107418"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030719","name":"National Institute of Health Sciences","doi-asserted-by":"publisher","award":["1RF1NS122880, NS133979 and AG085401"],"award-info":[{"award-number":["1RF1NS122880, NS133979 and AG085401"]}],"id":[{"id":"10.13039\/100030719","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Freedom Together Foundation"},{"name":"The Freedom Together Foundation"},{"name":"Thiemann Foundation and the German Research Foundation"},{"name":"Thiemann Foundation and the German Research Foundation"},{"name":"NIH\/NCI Cancer Support","award":["P30CA013696"],"award-info":[{"award-number":["P30CA013696"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,1,30]]},"abstract":"<jats:p>\u03b1-Synuclein (\u03b1Syn) is a presynaptic protein of unestablished physiological function that plays a central role in Parkinson\u2019s disease neuropathology. To date, the reported effects of \u03b1Syn expression on the kinetics of axonal synaptic vesicle exocytosis and membrane cycling have been relatively small. In contrast, we report that \u03b1Syn is the major modulator of substantia nigra somatodendritic dopamine release, a little-understood form of neurotransmission that is central to sensorimotor and basal ganglia circuitry. This regulation is due to a previously unknown role for \u03b1Syn in controlling the activity of the L-type calcium ion channels (LTCC), which are also implicated in Parkinson\u2019s pathogenesis. \u03b1Syn-deficient neurons further display decreased spike frequency adaptation, hippocampal LTCC-dependent long-term potentiation, and immediate early gene induction, functions that are essential for synaptic adaptation and neuronal plasticity.<\/jats:p>","DOI":"10.1126\/sciadv.ady6978","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T18:59:52Z","timestamp":1769626792000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":7,"title":["\u03b1-Synuclein expression is required for somatodendritic dopamine release and immediate early gene induction"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8229-1704","authenticated-orcid":true,"given":"Se Joon","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Molecular Therapeutics, New York State Psychiatric Institute, RFMH, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University Medical Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5645-0815","authenticated-orcid":true,"given":"Manu","family":"Ben-Johny","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9479-5331","authenticated-orcid":true,"given":"Guomei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University Medical Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9237-535X","authenticated-orcid":true,"given":"Jonas","family":"Bendig","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University Medical Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Fanourakis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University Medical Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-5318","authenticated-orcid":true,"given":"Benjamin D.","family":"Hobson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University Medical Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahalakshmi","family":"Somayaji","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University Medical Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9459-3593","authenticated-orcid":true,"given":"Nagendran","family":"Ramalingam","sequence":"additional","affiliation":[{"name":"Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA 02115."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6676-0107","authenticated-orcid":true,"given":"Ulf","family":"Dettmer","sequence":"additional","affiliation":[{"name":"Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA 02115."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7475-5006","authenticated-orcid":true,"given":"Ellen","family":"Kanter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University Medical Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-0439","authenticated-orcid":true,"given":"David","family":"Sulzer","sequence":"additional","affiliation":[{"name":"Division of Molecular Therapeutics, New York State Psychiatric Institute, RFMH, New York, NY, USA."},{"name":"Department of Psychiatry, Columbia University Medical Center, New York, NY, USA."},{"name":"Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY, USA."},{"name":"Department of Pharmacology, Columbia University Medical Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0229-7114","authenticated-orcid":true,"given":"Eugene V.","family":"Mosharov","sequence":"additional","affiliation":[{"name":"Division of Molecular Therapeutics, New York State Psychiatric Institute, RFMH, New York, NY, USA."},{"name":"Department of Psychiatry, Columbia University Medical Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb748"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.242"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-014-0077-y"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.09.004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2005.01.001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.487"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3955"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0155-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10030391"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80886-7"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2559-04.2004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6194-10.2011"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4529"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2013652117"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/pnasnexus\/pgad044"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.03.026"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.172514599"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.10.012"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.01.033"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0167-17.2017"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm6393"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.04.036"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00036"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0185"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.baga.2016.02.001"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0181-09.2009"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04059-0"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39805-7"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108951"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016787"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-19-07841.2001"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111915"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0459-16.2016"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019148"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.5607\/en.2017.26.4.179"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.759707"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106328"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.03.016"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12727"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200805048"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-023-00742-5"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.02.146"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.06.016"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406283101"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-022-01480-y"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.4.2181"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.3.1289"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.10.034"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.117896"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1531-05.2005"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/wmts.102"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes12081166"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/260258a0"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.16180"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.70921"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2023.168140"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114251"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00224"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3311"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05865"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00757.2013"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13572"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu131"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.18-0180"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0340903"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3717"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00161"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-021-00203-9"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01345-0"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100271"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.71385"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0305-17.2018"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004841"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxj037"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1716381115"}],"updated-by":[{"DOI":"10.1126\/sciadv.aeh5172","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000}}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.ady6978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:00:29Z","timestamp":1776448829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.ady6978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,1,30]]}},"alternative-id":["10.1126\/sciadv.ady6978"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.ady6978","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"2025-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eady6978"}}