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Adv."],"published-print":{"date-parts":[[2026,7,10]]},"abstract":"<jats:p>Cell-free DNA (cfDNA) in body fluids enables noninvasive cancer detection. Multifeature artificial intelligence (AI) can improve sensitivity by integrating diverse biomarkers when cancer signals are sparse. Tumor-informed assays that rely on mutations have limited practicality for early cancer detection. Emerging fragmentomic and epigenetic features underpin tumor-naive approaches to screening for individuals with low tumor burden. Here, we designed UNITE\u2014a universal cfDNA feature ensemble framework that provides scalable cancer detection methods based on \u201cgenomic bin\u2013fragment length\u201d matrices derived from shallow whole-genome sequencing (sWGS) data at 0.1\u00d7 depth. Using sWGS data from 2063 plasma samples (631 controls and 1432 cases from 26 cancer types), we systematically evaluated both XGBoost (UNITE-XGB) and convolutional neural networks (UNITE-CNN) across multiple feature spaces and cancer stages. In stage I-II cancer, UNITE-XGB and UNITE-CNN achieved 31 and 21% sensitivity, respectively, at 95% specificity. These findings provide roadmaps for developing multifeature AI beyond plasma biopsies.<\/jats:p>","DOI":"10.1126\/sciadv.ady9432","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:58:37Z","timestamp":1783706317000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7648-916X","authenticated-orcid":true,"given":"Haichao","family":"Wang","sequence":"first","affiliation":[{"name":"Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK."},{"name":"Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK."},{"name":"Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6967-1975","authenticated-orcid":true,"given":"Paulius D.","family":"Mennea","sequence":"additional","affiliation":[{"name":"Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK."},{"name":"Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK."},{"name":"Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grainne","family":"McAndrew","sequence":"additional","affiliation":[{"name":"Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK."},{"name":"Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK."},{"name":"Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2757-718X","authenticated-orcid":true,"given":"Ozge","family":"Sonmezler","sequence":"additional","affiliation":[{"name":"Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK."},{"name":"Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK."},{"name":"Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0266-7015","authenticated-orcid":true,"given":"Dmitry S.","family":"Shcherbo","sequence":"additional","affiliation":[{"name":"Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK."},{"name":"Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK."},{"name":"Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-7264","authenticated-orcid":true,"given":"Emma-Jane","family":"Ditter","sequence":"additional","affiliation":[{"name":"Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK."},{"name":"Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6044-3362","authenticated-orcid":true,"given":"Sarah \u00d8strup","family":"Jensen","sequence":"additional","affiliation":[{"name":"Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK."},{"name":"Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK."},{"name":"Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra I. 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