{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:31:26Z","timestamp":1786559486410,"version":"build-2736575974"},"reference-count":104,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"33","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82430053"],"award-info":[{"award-number":["82430053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82125001"],"award-info":[{"award-number":["82125001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471347"],"award-info":[{"award-number":["82471347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201948"],"award-info":[{"award-number":["82201948"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173393"],"award-info":[{"award-number":["82173393"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["24SF1904500"],"award-info":[{"award-number":["24SF1904500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Program of Shanghai Municipal Education Commission","award":["2023ZKZD33"],"award-info":[{"award-number":["2023ZKZD33"]}]},{"DOI":"10.13039\/501100017536","name":"Shanghai Pulmonary Hospital","doi-asserted-by":"publisher","award":["TJ-FK-YXJC003"],"award-info":[{"award-number":["TJ-FK-YXJC003"]}],"id":[{"id":"10.13039\/501100017536","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017536","name":"Shanghai Pulmonary Hospital","doi-asserted-by":"publisher","award":["LYRC202402"],"award-info":[{"award-number":["LYRC202402"]}],"id":[{"id":"10.13039\/501100017536","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017536","name":"Shanghai Pulmonary Hospital","doi-asserted-by":"publisher","award":["FKLY20004"],"award-info":[{"award-number":["FKLY20004"]}],"id":[{"id":"10.13039\/501100017536","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017536","name":"Shanghai Pulmonary Hospital","doi-asserted-by":"publisher","award":["FKYQ2308"],"award-info":[{"award-number":["FKYQ2308"]}],"id":[{"id":"10.13039\/501100017536","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:p>\n                    Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare yet highly aggressive subtype of non-small cell lung carcinoma (NSCLC) with limited therapeutic options. We conduct a comprehensive proteogenomic analysis of LCNEC using tumors and paired normal adjacent tissues from 107 patients (81 pure LCNEC and 26 combined LCNEC). APOBEC mutational signatures strongly correlate processes of tumor initiation and immune suppression, and\n                    <jats:italic toggle=\"yes\">KEAP1<\/jats:italic>\n                    mutations correlate with metabolic reprogramming in LCNEC combined with NSCLC. A conflicting relationship is observed between neuroendocrine and immune phenotypes. We identify three LCNEC subtypes with unique prognosis features, microenvironment dysregulation, genetic alterations, and potential therapeutic targets. Interleukin-33 (IL-33) emerges as a critical therapeutic biomarker associated with enhanced T cell infiltration and antitumor activity. We further optimize recombinant IL-33 (rIL33) with site-directed mutagenesis and develop PEGylated rIL33, demonstrating its prolonged circulation time in cynomolgus monkeys and superior immune agonist activity in mouse models. Overall, this study offers insights into LCNEC biology and provides promising innovative immunoagonist therapy strategies for lung cancer.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adz0583","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:01:07Z","timestamp":1786557667000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Proteogenomic characterization of pulmonary large-cell neuroendocrine carcinoma identifies molecular features and therapeutic strategy"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5595-3103","authenticated-orcid":true,"given":"Lele","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China."},{"name":"Central Laboratory, Innovation and Incubation Center, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangdong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9818-0924","authenticated-orcid":true,"given":"Shengnan","family":"Duan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilv","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2866-7851","authenticated-orcid":true,"given":"Jinyi","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1386-4910","authenticated-orcid":true,"given":"Linghui","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huansha","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Animal Experimental Center, Innovation and Incubation Center, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3713-2635","authenticated-orcid":true,"given":"Jijun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wang","sequence":"additional","affiliation":[{"name":"Tissue Bank, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0773-3886","authenticated-orcid":true,"given":"Lu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China."},{"name":"Central Laboratory, Innovation and Incubation Center, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5079-2040","authenticated-orcid":true,"given":"Jue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7006-4737","authenticated-orcid":true,"given":"Hu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4948-0469","authenticated-orcid":true,"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5348-5641","authenticated-orcid":true,"given":"Haiyang","family":"Hu","sequence":"additional","affiliation":[{"name":"Central Laboratory, Innovation and Incubation Center, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-9275","authenticated-orcid":true,"given":"Ming","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1771-7545","authenticated-orcid":true,"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq380"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000630"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2019.07.011"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00618-2015"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00128-2016"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000589"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0355"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2946"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4314"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03099-x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.013"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.07.016"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.043"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.012"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.030"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.12.007"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-1921"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63091-0"},{"key":"e_1_3_2_22_2","first-page":"D863","article-title":"DriverDBv3: A multi-omics database for cancer driver gene research","volume":"48","author":"Liu S. H.","year":"2020","unstructured":"S. H. Liu, P. C. Shen, C. Y. Chen, A. N. Hsu, Y. C. Cho, Y. L. Lai, F. H. Chen, C. Y. Li, S. C. Wang, M. Chen, I. F. Chung, W. C. Cheng, DriverDBv3: A multi-omics database for cancer driver gene research. Nucleic Acids Res. 48, D863\u2013D870 (2020).","journal-title":"Nucleic Acids Res."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000250"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-20-0161"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31975"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2022.07.004"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.143"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21099-2"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.060"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06564-w"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1423026112"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2023.07.001"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03620-3"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.21125"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0775"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-20-0500"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.02.018"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4407"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1349-1"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0136-1"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01142-2"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23344"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0245-9"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02444-8"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01566-8"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0512-0"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1091-2"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2023868118"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.12.004"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2012.01.008"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103457"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.624079"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg542"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2019.0073"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep20460"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12957"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-3059"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114248"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0745-2"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-014-8516-1"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0045-z"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-21-0952"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00746-x"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aas9668"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.03.018"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abk1023"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.051"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2020.03.008"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2021.02.003"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-017-0281-y"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-23-150"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.02.006"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3370"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.9b00759"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0051-x"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009557"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12213"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2702"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004873"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-4-r41"},{"key":"e_1_3_2_81_2","first-page":"15","article-title":"STAR: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin A.","year":"2013","unstructured":"A. Dobin, C. A. Davis, F. Schlesinger, J. Drenkow, C. Zaleski, S. Jha, P. Batut, M. Chaisson, T. R. Gingeras, STAR: Ultrafast universal RNA-seq aligner. Bioinf. (Oxf.) 29, 15\u201321 (2013).","journal-title":"Bioinf. (Oxf.)"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4197"},{"key":"e_1_3_2_83_2","doi-asserted-by":"crossref","unstructured":"W. Ma S. Kim S. Chowdhury Z. Li M. Yang S. Yoo F. Petralia J. Jacobsen J. J. Li X. Ge K. Li T. Yu N. Edwards S. Payne P. C. Boutros H. Rodriguez G. Stolovitzky J. Zhu J. Kang D. Fenyo J. Saez-Rodriguez P. Wang DreamAI: Algorithm for the imputation of proteomics data. bioRxiv 214205 [Preprint] (2020). https:\/\/biorxiv.org\/content\/10.1101\/2020.07.21.214205v2.","DOI":"10.1101\/2020.07.21.214205"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx415"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2003573"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1267"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2968"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.02.009"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.159"},{"key":"e_1_3_2_92_2","first-page":"1572","article-title":"ConsensusClusterPlus: A class discovery tool with confidence assessments and item tracking","volume":"26","author":"Wilkerson M. D.","year":"2010","unstructured":"M. D. Wilkerson, D. N. Hayes, ConsensusClusterPlus: A class discovery tool with confidence assessments and item tracking. Bioinf. (Oxf.) 26, 1572\u20131573 (2010).","journal-title":"Bioinf. (Oxf.)"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3612"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2006.26.462"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-7"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3458"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.029"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-367"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308531101"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2018.02.02"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075762"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1011"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2011-015"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2019.03.003"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adz0583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:04:06Z","timestamp":1786557846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adz0583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":104,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2026,8,14]]}},"alternative-id":["10.1126\/sciadv.adz0583"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adz0583","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]},"assertion":[{"value":"2025-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadz0583"}}