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Adv."],"published-print":{"date-parts":[[2026,6,12]]},"abstract":"<jats:p>\n                    Normal heart contraction requires synchronized calcium ion (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) release from the sarcoplasmic reticulum (SR), traditionally attributed to ryanodine receptor 2 (RyR2). Here, we identify vacuole membrane protein 1 (VMP1) as a previously unrecognized SR Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release channel essential for postnatal cardiac function. VMP1 expression is up-regulated in cardiomyocytes after birth, and its genetic deletion causes severe arrhythmias, dilated cardiomyopathy, and sudden cardiac death. Mechanistically, VMP1 loss results in increased SR Ca\n                    <jats:sup>2+<\/jats:sup>\n                    content and aberrant cardiac action potentials. Single-channel electrophysiology reveals that VMP1 forms a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -regulated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel, which senses luminal Ca\n                    <jats:sup>2+<\/jats:sup>\n                    via aspartic acid 272. Notably, VMP1 expression is elevated in human heart failure, suggesting a pathophysiological role. These findings establish VMP1 as a critical component of the cardiac Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release machinery and uncover its involvement in heart failure.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adz0706","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:58:47Z","timestamp":1781287127000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["VMP1 forms a Ca\n                    <sup>2+<\/sup>\n                    release channel essential for postnatal heartbeat"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0541-2506","authenticated-orcid":true,"given":"Yuying","family":"Ma","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Oncology, Institute for Immunology, Beijing Key Laboratory of Immunological Research of Allergy, School of Basic Medical Sciences, Tsinghua Medicine, Tsinghua University, Beijing, China."},{"name":"SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine, Shanxi Medical University, Taiyuan, Shanxi Province, China."},{"name":"Tsinghua-Peking Center for Life Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8425-7712","authenticated-orcid":true,"given":"Qiguang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China."},{"name":"University of Chinese Academy of Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8110-0817","authenticated-orcid":true,"given":"Yuting","family":"Jia","sequence":"additional","affiliation":[{"name":"SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine, Shanxi Medical University, Taiyuan, Shanxi 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Key Laboratory of Molecular Oncology, Institute for Immunology, Beijing Key Laboratory of Immunological Research of Allergy, School of Basic Medical Sciences, Tsinghua Medicine, Tsinghua University, Beijing, China."},{"name":"SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine, Shanxi Medical University, Taiyuan, Shanxi Province, China."},{"name":"Tsinghua-Peking Center for Life Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-4459","authenticated-orcid":true,"given":"Sui","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China."},{"name":"University of Chinese Academy of Sciences, Beijing, 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