{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:32:03Z","timestamp":1792794723139,"version":"4.5.0"},"reference-count":71,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"12","funder":[{"DOI":"10.13039\/100008590","name":"Dr. Ralph and Marian Falk Medical Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,3,20]]},"abstract":"<jats:p>\n                    Wound infections are becoming increasingly difficult to treat due to rising antibiotic-resistant bacteria. \u03b2-Lactamase\u2013producing bacteria are among the most common pathogens implicated in these infections. Here, we report a bacterial enzyme-responsive hydrogel formulated with a cephalosporin-derived, \u03b2-lactamase\u2013cleavable crosslinker that undergoes selective degradation in the presence of bacterial \u03b2-lactamases. This degradation triggers the on-demand release of encapsulated ciprofloxacin-loaded liposomes, ensuring that antibiotic delivery occurs only at the site of infection. This selective degradation and release was demonstrated in both ex vivo and in vivo models of\n                    <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                    wound infections. In a murine skin abrasion infection model, a single application of the hydrogel led to complete bacterial eradication and enhanced wound healing, outperforming a commercial silver-based hydrogel wound dressing. These responsive hydrogels did not induce ciprofloxacin resistance in non\u2013\u03b2-lactamase\u2013producing bacteria. These findings demonstrate that \u03b2-lactamase\u2013responsive hydrogels provide a precise, infection-triggered antibiotic delivery platform that can improve the treatment of wound infections and mitigate antimicrobial resistance.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adz0786","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T18:01:06Z","timestamp":1774029666000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":18,"title":["Bacterial enzyme-responsive hydrogels for triggered delivery of antibiotics to infected wounds"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2877-8204","authenticated-orcid":true,"given":"Akram","family":"Abbasi","sequence":"first","affiliation":[{"name":"School of Engineering, Institute for Biology, Engineering, and Medicine, Brown University, Providence, RI, 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